Neurological Disorders

Neurological disorders are diseases that affect the brain, spinal cord, peripheral nerves, and other components of the nervous system. These diseases include, but are not limited to, cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and epilepsy.

For neurological disease drugs, drug discovery strategies include phenotype-based drug discovery (PDD) and target-based drug discovery (TDD).PDD discovers clinically valuable drugs through biological assays and translational medicine markers, while TDD focuses on the development of drugs with known targets. The drug targets corresponding to different diseases are as follows:

Cerebrovascular diseases: platelet aggregation, angiotensin-converting enzyme (ACE), angiotensin receptor, P2Y12 receptor, etc.
Parkinson's disease: dopamine receptor, monoamine oxidase B (MAO-B), catechol-O-methyltransferase (COMT), etc.
Alzheimer's disease: β-amyloid (Aβ), Tau protein, acetylcholinesterase (AChE), etc.
Multiple sclerosis: S1P receptor, interferon, etc.
Epilepsy: voltage-gated sodium channels, GABA receptors, AMPA receptors, etc.

Neurological Disorders Drug Targets

Neurological Disorders Drug Target Related Products

● Target Proteins

MAPT
CSB-MP013481HU(F8)

CSB-MP013481HU(F8) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human MAPT at 2 μg/ml can bind Anti-MAPT recombinant antibody (CSB-RA013481A1HU), the EC₅₀ is 4.547-6.284 ng/mL.

GHR
CSB-MP009411HU

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU

CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

GLP1R
CSB-MP009514HUb1

CSB-MP009514HUb1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

EGFR
CSB-MP007479HU

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

PDCD1
CSB-MP619964HU1

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD40LG
CSB-MP004937HU3

CSB-MP004937HU3 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CD274
CSB-MP878942HU1

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL