PGRN

The progranulin (PGRN) is a secretory glycoprotein composed of multiple tandemly repeated structural domains, capable of hydrolyzing into various granulin peptides. It exhibits broad specificity in cells and tissues, exerting diverse functions through binding with multiple receptors, such as regulating immune cell function and promoting neural regeneration. In neurons, PGRN is secreted in an activity-dependent manner, influencing synaptic structure and function. Although the signaling pathway mechanism of PGRN is not fully understood, it is known to play a crucial role in immune responses and neural system functions, and may be associated with familial neurodegenerative diseases.

Popular Product:

Human Granulins(GRN) ELISA kit

Validated Data

Typical Data

Code：CSB-EL009939HU

Size：96T/48T

Sensitivity：1.95 pg/mL

Detection Range：7.8 pg/mL-500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.