IL2RA

The IL2RA gene encodes the Interleukin-2 receptor subunit alpha, commonly known as CD25. This protein is a key component of the high - affinity interleukin - 2 receptor complex. It binds interleukin - 2, initiating a signaling cascade that activates T - lymphocytes, which play a crucial role in the immune response. The JAK - STAT pathway is the main signaling route involved.
Dysregulation of IL2RA is associated with various autoimmune diseases like multiple sclerosis and type 1 diabetes. In drug development, anti - CD25 monoclonal antibodies have been investigated for immunosuppressive therapies. These agents aim to block the interaction between interleukin - 2 and CD25, providing potential treatments for immune - related disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Human IL2(CSB-MP011629HU)，the EC₅₀ is 1.693-2.039 ng/mL.

Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial (Active)(CSB-MP011649MO1)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Il2ra at 2 μg/ml can bind Mouse Il2 (CSB-MP011629MOd9). The EC₅₀ is 95.00-116.2 ng/mL.

The purity of Il2ra was greater than 95% as determined by SEC-HPLC

IL2RA Recombinant Monoclonal Antibody(CSB-RA011649MA1HU)

Validated Data

IL2RA Recombinant Monoclonal Antibody

Human soluble interleukin-2 receptor,IL-2sRα ELISA kit(CSB-E04629h)

Validated Data

Human soluble interleukin-2 receptor,IL-2sRα ELISA kit

The following IL2RA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IL2RA Antibodies

IL2RA Proteins

IL2RA ELISA Kits

IL2RA Antibodies

IL2RA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-MA000266	IL2RA Monoclonal Antibody	Human	ELISA,IHC
CSB-PA005198	IL2RA Antibody	Human	WB, ELISA
CSB-PA009542	Phospho-IL2RA (S268) Antibody	Human	WB, IHC, IF, ELISA
CSB-PA009543	IL2RA Antibody	Human	WB, IF, ELISA
CSB-PA904921	IL2RA Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA013952	IL2RA Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA011649LA01HU	IL2RA Antibody	Human, Rat	ELISA, WB, IHC, IF
CSB-PA011649LC01HU	IL2RA Antibody, FITC conjugated	Human
CSB-PA011649LD01HU	IL2RA Antibody, Biotin conjugated	Human	ELISA
CSB-RA011649MA1HU	IL2RA Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-RA011649MB1HU	IL2RA (Basiliximab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA011649MB2HU	IL2RA (BA-1106 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA011649MB3HU	IL2RA (Daclizumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA011649MB4HU	IL2RA (Imneskibart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA011649MB5HU	IL2RA (dacliximab Biosimilar) Recombinant Monoclonal Antibody	Human

IL2RA Proteins

IL2RA Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP656443EQV CSB-EP656443EQV CSB-BP656443EQV CSB-MP656443EQV CSB-EP656443EQV-B	Recombinant Pan troglodytes Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF011649DO	Recombinant Dog Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649DO1 CSB-EP011649DO1 CSB-BP011649DO1 CSB-MP011649DO1 CSB-EP011649DO1-B	Recombinant Dog Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF011649SH	Recombinant Sheep Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649SH1 CSB-EP011649SH1 CSB-BP011649SH1 CSB-MP011649SH1 CSB-EP011649SH1-B	Recombinant Sheep Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF011649CA	Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649CA1 CSB-EP011649CA1 CSB-BP011649CA1 CSB-MP011649CA1 CSB-EP011649CA1-B	Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-MP5104MOVd9	Recombinant Macaca fascicularis Interleukin-2 receptor subunit alpha (IL2RA), partial	Mammalian cell
CSB-MP5104MOV	Recombinant Macaca fascicularis Interleukin-2 receptor subunit alpha (IL2RA), partial (Active)	Mammalian cell

IL2RA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF011649HU	Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649HU1 CSB-EP011649HU1 CSB-BP011649HU1 CSB-MP011649HU1 CSB-EP011649HU1-B	Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011649HU2	Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial	E.coli
CSB-MP011649HU3	Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active)	Mammalian cell

IL2RA Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF011649RA	Recombinant Rat Interleukin-2 receptor subunit alpha (Il2ra)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649RA1 CSB-EP011649RA1 CSB-BP011649RA1 CSB-MP011649RA1 CSB-EP011649RA1-B	Recombinant Rat Interleukin-2 receptor subunit alpha (Il2ra), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF011649PI	Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649PI1 CSB-EP011649PI1 CSB-BP011649PI1 CSB-MP011649PI1 CSB-EP011649PI1-B	Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011649PI1	Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA), partial	E.coli
CSB-YP011649PI1	Recombinant Pig Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast

IL2RA Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP689641MOW CSB-EP689641MOW CSB-BP689641MOW CSB-MP689641MOW CSB-EP689641MOW-B	Recombinant Macaca mulatta Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF011649BO	Recombinant Bovine Interleukin-2 receptor subunit alpha (IL2RA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649BO1 CSB-EP011649BO1 CSB-BP011649BO1 CSB-MP011649BO1 CSB-EP011649BO1-B	Recombinant Bovine Interleukin-2 receptor subunit alpha (IL2RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL2RA Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF011649MO	Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP011649MO1 CSB-EP011649MO1 CSB-BP011649MO1 CSB-MP011649MO1 CSB-EP011649MO1-B	Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP011649MO1d9	Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial	Mammalian cell
CSB-MP011649MO1	Recombinant Mouse Interleukin-2 receptor subunit alpha (Il2ra), partial (Active)	Mammalian cell

IL2RA ELISA Kit

IL2RA ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E04629h	Human soluble interleukin-2 receptor,IL-2sRα ELISA kit	serum, plasma, tissue homogenates	19.5 pg/mL

IL2RA ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E07440m	Mouse soluble interleukin-2 receptor,sIL-2Rα ELISA kit	serum, plasma, tissue homogenates	3.9 pg/ml

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IL2RA

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