CD80

CD80, also known as B7-1 or BB1, is a crucial costimulatory molecule expressed on various cell types, including activated B cells, T cells, macrophages, and tumor cells. Its primary function is to interact with CD28 on T cells, facilitating T-cell activation and proliferation. CD80 is involved in several signaling pathways, including those involving PD-L1 and CTLA-4, which regulate immune responses and tumor growth. CD80 expression is associated with various diseases, such as multiple sclerosis, systemic lupus erythematosus, and certain types of cancer. In drug development, CD80-targeted therapies, including fusion proteins, monoclonal antibodies, and CAR T-cell therapies, are being investigated for their potential in treating cancer and autoimmune diseases.