MSTN

MSTN, also known as myostatin, is a secretory protein that plays a crucial regulatory role in the musculoskeletal system of mammals and belongs to the TGF-β superfamily. Its structure includes an N-terminal secretory signal peptide and a cysteine structure. By binding to its receptor, MSTN inhibits the growth, differentiation, and proliferation of muscle cells, thereby regulating muscle development. In the process of signal transduction, MSTN forms a complex with intracellular receptors, activating Smads proteins, phosphorylating them, and entering the nucleus to regulate the expression of target genes. Additionally, MSTN is involved in the transduction of signaling pathways such as MAPK and p38, which affect the proliferative cycle of muscle cells. The complex structure and functions of MSTN endow it with broad application prospects in biology and medicine, especially in the regulation of muscle growth, disease treatment, and the development of myotonic agents.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MSTN(GDF-8) at 2 μg/ml can bind Human ACVR2B (CSB-MP623829HUi9). The EC₅₀ is 68.26-74.59 ng/mL.

MSTN Antibody(CSB-PA11869A0Rb)

Validated Data

Western Blot
Positive WB detected in: 293T whole cell lysate, Hela whole cell lysate, U251 whole cell lysate
All lanes: MSTN antibody at 4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA11869A0Rb at dilution of 1:100

Human Myostatin,MSTN ELISA Kit(CSB-E11300h)

Validated Data

Code: CSB-E11300h

Size: 96T,5×96T,10×96T

Sensitivity: 0.312 ng/mL

Detection Range: 0.625 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following MSTN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MSTN Antibodies

MSTN Proteins

MSTN ELISA Kits

MSTN Antibodies

MSTN Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA015057GA01HU	MSTN Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA11869A0Rb	MSTN Antibody	Human	ELISA, WB, IHC
CSB-PA11869B0Rb	MSTN Antibody, HRP conjugated	Human	ELISA
CSB-PA008776	MSTN Antibody	Human,Mouse	IHC, ELISA
CSB-PA293957	MSTN Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA015057MB3HU	MSTN (Trevogrumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA015057MB1HU	MSTN (Apitegromab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA015057MB2HU	MSTN (Emugrobart Biosimilar) Recombinant Monoclonal Antibody	Human

MSTN Proteins

MSTN Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP861952HO CSB-EP861952HO CSB-BP861952HO CSB-MP861952HO CSB-EP861952HO-B	Recombinant Horse Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP861952HO	Recombinant Horse Growth/differentiation factor 8 (MSTN)	E.coli

MSTN Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP015057PI CSB-EP015057PI CSB-BP015057PI CSB-MP015057PI CSB-EP015057PI-B	Recombinant Pig Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Antilocapra americana (Pronghorn)

Code	Product Name	Source
CSB-YP722741ALS CSB-EP722741ALS CSB-BP722741ALS CSB-MP722741ALS CSB-EP722741ALS-B	Recombinant Antilocapra americana Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Vulpes lagopus (Arctic fox) (Alopex lagopus)

Code	Product Name	Source
CSB-YP753726VFU CSB-EP753726VFU CSB-BP753726VFU CSB-MP753726VFU CSB-EP753726VFU-B	Recombinant Vulpes lagopus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Anser anser anser (Western greylag goose)

Code	Product Name	Source
CSB-YP823712AKX CSB-EP823712AKX CSB-BP823712AKX CSB-MP823712AKX CSB-EP823712AKX-B	Recombinant Anser anser anser Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-EP3992CA	Recombinant Cat Growth/differentiation factor 8 (MSTN)	E.coli
CSB-MP3992CA	Recombinant Cat Growth/differentiation factor 8 (MSTN)	Mammalian cell

MSTN Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP822080MOV CSB-EP822080MOV CSB-BP822080MOV CSB-MP822080MOV CSB-EP822080MOV-B	Recombinant Macaca fascicularis Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Columba livia (Rock dove)

Code	Product Name	Source
CSB-YP844970DVK CSB-EP844970DVK CSB-BP844970DVK CSB-MP844970DVK CSB-EP844970DVK-B	Recombinant Columba livia Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Synoicus chinensis (Blue-breasted quail) (Coturnix chinensis)

Code	Product Name	Source
CSB-YP855300CIAU CSB-EP855300CIAU CSB-BP855300CIAU CSB-MP855300CIAU CSB-EP855300CIAU-B	Recombinant Coturnix chinensis Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Bos gaurus (Seladang) (Indian bison)

Code	Product Name	Source
CSB-YP733108BIQ CSB-EP733108BIQ CSB-BP733108BIQ CSB-MP733108BIQ CSB-EP733108BIQ-B	Recombinant Bos gaurus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Meleagris gallopavo (Wild turkey)

Code	Product Name	Source
CSB-YP015057MQV CSB-EP015057MQV CSB-BP015057MQV CSB-MP015057MQV CSB-EP015057MQV-B	Recombinant Meleagris gallopavo Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP015057MO CSB-EP015057MO CSB-BP015057MO CSB-MP015057MO CSB-EP015057MO-B	Recombinant Mouse Growth/differentiation factor 8 (Mstn)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Anas platyrhynchos (Mallard) (Anas boschas)

Code	Product Name	Source
CSB-YP837682BZD CSB-EP837682BZD CSB-BP837682BZD CSB-MP837682BZD CSB-EP837682BZD-B	Recombinant Anas platyrhynchos Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Capra hircus (Goat)

Code	Product Name	Source
CSB-YP744218GO CSB-EP744218GO CSB-BP744218GO CSB-MP744218GO CSB-EP744218GO-B	Recombinant Goat Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Capra ibex (Ibex)

Code	Product Name	Source
CSB-YP736150CZZ CSB-EP736150CZZ CSB-BP736150CZZ CSB-MP736150CZZ CSB-EP736150CZZ-B	Recombinant Capra ibex Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Pongo pygmaeus (Bornean orangutan)

Code	Product Name	Source
CSB-YP015057EXP CSB-EP015057EXP CSB-BP015057EXP CSB-MP015057EXP CSB-EP015057EXP-B	Recombinant Pongo pygmaeus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP015057EQV CSB-EP015057EQV CSB-BP015057EQV CSB-MP015057EQV CSB-EP015057EQV-B	Recombinant Pan troglodytes Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

Code	Product Name	Source
CSB-YP015057EQU CSB-EP015057EQU CSB-BP015057EQU CSB-MP015057EQU CSB-EP015057EQU-B	Recombinant Pan paniscus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP015057CH CSB-EP015057CH CSB-BP015057CH CSB-MP015057CH CSB-EP015057CH-B	Recombinant Chicken Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP015057HU CSB-EP015057HU CSB-BP015057HU CSB-MP015057HU CSB-EP015057HU-B	Recombinant Human Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP015057HU	Recombinant Human Growth/differentiation factor 8 (MSTN)	E.coli
CSB-EP015057HUd7	Recombinant Human Growth/differentiation factor 8 (MSTN)	E.coli
CSB-MP015057HU	Recombinant Human Growth/differentiation factor 8 (MSTN)	Mammalian cell
CSB-MP015057HU(A4)d7	Recombinant Human Growth/differentiation factor 8 (MSTN)	Mammalian cell
CSB-MP015057HU(A4)	Recombinant Human Growth/differentiation factor 8 (MSTN) (Active)	Mammalian cell

MSTN Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP015057MOW CSB-EP015057MOW CSB-BP015057MOW CSB-MP015057MOW CSB-EP015057MOW-B	Recombinant Macaca mulatta (Rhesus macaque) Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Bos indicus (Zebu)

Code	Product Name	Source
CSB-YP722492BUL CSB-EP722492BUL CSB-BP722492BUL CSB-MP722492BUL CSB-EP722492BUL-B	Recombinant Bos indicus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Papio hamadryas (Hamadryas baboon)

Code	Product Name	Source
CSB-YP015057ERJ CSB-EP015057ERJ CSB-BP015057ERJ CSB-MP015057ERJ CSB-EP015057ERJ-B	Recombinant Papio hamadryas Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP015057BO CSB-EP015057BO CSB-BP015057BO CSB-MP015057BO CSB-EP015057BO-B	Recombinant Bovine Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Bubalus bubalis (Domestic water buffalo)

Code	Product Name	Source
CSB-YP757839BWX CSB-EP757839BWX CSB-BP757839BWX CSB-MP757839BWX CSB-EP757839BWX-B	Recombinant Bubalus bubalis Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Lepus capensis (Brown hare)

Code	Product Name	Source
CSB-YP815503LEX CSB-EP815503LEX CSB-BP815503LEX CSB-MP815503LEX CSB-EP815503LEX-B	Recombinant Lepus capensis Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Vulpes vulpes (Red fox)

Code	Product Name	Source
CSB-YP718793VFW CSB-EP718793VFW CSB-BP718793VFW CSB-MP718793VFW CSB-EP718793VFW-B	Recombinant Vulpes vulpes Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP761481DO CSB-EP761481DO CSB-BP761481DO CSB-MP761481DO CSB-EP761481DO-B	Recombinant Dog Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP761481DOa0	Recombinant Dog Growth/differentiation factor 8 (MSTN)	E.coli
CSB-EP761481DO	Recombinant Dog Growth/differentiation factor 8 (MSTN)	E.coli

MSTN Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

Code	Product Name	Source
CSB-YP015057GGZ CSB-EP015057GGZ CSB-BP015057GGZ CSB-MP015057GGZ CSB-EP015057GGZ-B	Recombinant Gorilla gorilla gorilla Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP015057SH CSB-EP015057SH CSB-BP015057SH CSB-MP015057SH CSB-EP015057SH-B	Recombinant Sheep Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Hemitragus jemlahicus (Himalayan tahr)

Code	Product Name	Source
CSB-YP729383HVM CSB-EP729383HVM CSB-BP729383HVM CSB-MP729383HVM CSB-EP729383HVM-B	Recombinant Hemitragus jemlahicus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP015057RA CSB-EP015057RA CSB-BP015057RA CSB-MP015057RA CSB-EP015057RA-B	Recombinant Rat Growth/differentiation factor 8 (Mstn)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Taurotragus derbianus (Giant eland) (Derby eland)

Code	Product Name	Source
CSB-YP733107TLL CSB-EP733107TLL CSB-BP733107TLL CSB-MP733107TLL CSB-EP733107TLL-B	Recombinant Taurotragus derbianus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Coturnix coturnix (Common quail) (Tetrao coturnix)

Code	Product Name	Source
CSB-YP807292CRA CSB-EP807292CRA CSB-BP807292CRA CSB-MP807292CRA CSB-EP807292CRA-B	Recombinant Coturnix coturnix Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Sylvicapra grimmia (Grey duiker)

Code	Product Name	Source
CSB-YP726061SFAM CSB-EP726061SFAM CSB-BP726061SFAM CSB-MP726061SFAM CSB-EP726061SFAM-B	Recombinant Sylvicapra grimmia Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MSTN Proteins for Aepyceros melampus (Impala)

Code	Product Name	Source
CSB-YP719573AXU CSB-EP719573AXU CSB-BP719573AXU CSB-MP719573AXU CSB-EP719573AXU-B	Recombinant Aepyceros melampus Growth/differentiation factor 8 (MSTN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli