Transthyretin (TTR), synthesized by the liver and choroid plexus, plays a pivotal role in the transportation of thyroid hormones, T4 and T3, and vitamin A by binding to retinol. This transport function is critical for maintaining the equilibrium of these essential substances, which are imperative for a range of physiological processes including growth, development, metabolic regulation, and visual function. When TTR misfolds, it can aggregate into amyloid plaques, a hallmark of hereditary amyloid polyneuropathy (hATTR), leading to significant damage to the nervous system and organ dysfunction. The study of TTR is importance for advancing our comprehension of hATTR and for the development of targeted treatment approaches to mitigate the impact of this disease.
Popular
Product:
Recombinant Human Transthyretin (TTR) (Active)(CSB-MP025270HUh6)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized RBP4 (CSB-MP019483HU) at 5 μg/ml can bind human TTR, the EC50 of human TTR protein is 284.7-391.7 ng/ml.
TTR Recombinant Monoclonal Antibody(CSB-RA437590A0HU)
Validated Data
IHC image of CSB-RA437590A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following TTR
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
TTR Proteins
TTR Proteins for Pan troglodytes (Chimpanzee)
TTR Proteins for Petaurus breviceps (Australian sugar glider)
TTR Proteins for Macropus giganteus (Eastern gray kangaroo)
TTR Proteins for Gallus gallus (Chicken)
TTR Proteins for Homo sapiens (Human)
TTR Proteins for Sus scrofa (Pig)
TTR Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
TTR Proteins for Sminthopsis macroura (Stripe-faced dunnart)
TTR Proteins for Tiliqua rugosa (Shingleback lizard) (Trachydosaurus rugosus)
TTR Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
TTR Proteins for Bos taurus (Bovine)
TTR Proteins for Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile)
TTR Proteins for Erinaceus europaeus (Western European hedgehog)
TTR Proteins for Macropus eugenii (Tammar wallaby) (Notamacropus eugenii)
TTR Proteins for Xenopus laevis (African clawed frog)
TTR Proteins for Pseudomonas amygdali pv. tabaci (Pseudomonas syringae pv. tabaci)
TTR Proteins for Ovis aries (Sheep)
TTR Proteins for Sorex araneus (Eurasian common shrew) (European shrew)
TTR Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
TTR Proteins for Rattus norvegicus (Rat)
TTR Proteins for Oryctolagus cuniculus (Rabbit)
TTR Proteins for Monodelphis domestica (Gray short-tailed opossum)
TTR Proteins for Mus musculus (Mouse)
