SNCA

The SNCA gene encodes α-synuclein, a presynaptic protein with key roles in synaptic vesicle trafficking and neurotransmitter release. Also known as NACP, this 140-amino acid protein regulates SNARE complex assembly and dopamine homeostasis. Its aggregation into Lewy bodies is a pathological hallmark of synucleinopathies.
α-Synuclein interacts with the ubiquitin-proteasome system and autophagy pathways, influencing protein degradation. Mutations or triplications cause familial Parkinson’s disease, while its misfolding links to dementia with Lewy bodies. Current drug development targets aggregation inhibitors and immunotherapies to reduce pathogenic protein load.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SNCA Recombinant Monoclonal Antibody(CSB-RA021912MA1HU)

Validated Data

IHC image of CSB-RA021912MA1HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA021912MA1HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of SH-SY5Y cell with CSB-RA021912MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA021912MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

SNCA Antibody(CSB-PA06994A0Rb)

Validated Data

Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: SNCA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 15 kDa
Observed band size: 15 kDa

Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA06994A0Rb at dilution of 1:100

Human alpha-synuclein （SNCA）ELISA kit(CSB-E18033h)

Validated Data

Code: CSB-E18033h

Size: 96T,5×96T,10×96T

Sensitivity: 0.078 ng/mL

Detection Range: 0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following SNCA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SNCA Antibodies

SNCA Proteins

SNCA ELISA Kits

SNCA Antibodies

SNCA Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Species Reactivity	Application
CSB-PA021912ZA01MOV	SNCA Antibody	Macaca fascicularis	ELISA, WB (ensure identification of antigen)

SNCA Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA021912DA01RA	Snca Antibody	Rat	ELISA

SNCA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA021912GA01HU	SNCA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA06994A0Rb	SNCA Antibody	Human	ELISA, WB, IHC
CSB-PA06994B0Rb	SNCA Antibody, HRP conjugated	Human	ELISA
CSB-PA06994D0Rb	SNCA Antibody, Biotin conjugated	Human	ELISA
CSB-PA06997C0Rb	SNCA Antibody, FITC conjugated	Human
CSB-PA06997D0Rb	SNCA Antibody, Biotin conjugated	Human	ELISA
CSB-PA06997A0Rb	SNCA Antibody	Human	ELISA, IHC, IF
CSB-PA021912DSR1HU	SNCA Antibody	Human	ELISA, IHC
CSB-PA585265	Phospho-SNCA (Ser129) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA145405	Phospho-SNCA (Tyr125) Antibody	Human	ELISA,WB,IF
CSB-PA053564	Phospho-SNCA (Tyr133) Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA783926	SNCA (Ab-133) Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA238735	SNCA (Ab-129) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA578342	SNCA (Ab-125) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA036896	SNCA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA000748	Phospho-SNCA (Y125) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA004209	SNCA Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA004210	SNCA Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA004212	SNCA Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA050113	Phospho-SNCA (S129) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050114	Phospho-SNCA (Y133) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050115	Phospho-SNCA (Y136) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA050116	SNCA Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA592134	SNCA Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA169656	SNCA Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA021912OA01HU	SNCA Antibody	Human	ELISA, IHC, IF
CSB-PA021912OB01HU	SNCA Antibody, HRP conjugated	Human	ELISA
CSB-PA021912OD01HU	SNCA Antibody, Biotin conjugated	Human	ELISA
CSB-RA021912A129phHU	Phospho-SNCA (S129) Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF
CSB-RA585595A0HU	SNCA Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA021912MA1HU	SNCA Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF, FC
CSB-RA021912MB5HU	SNCA (UCB-7853 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA021912MB1HU	SNCA (Amlenetug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA021912MB2HU	SNCA (Exidavnemab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA021912MB3HU	SNCA (Indenebart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA021912MB4HU	SNCA (Prasinezumab Biosimilar) Recombinant Monoclonal Antibody	Human

SNCA Antibodies for Sus scrofa (Pig)

Code	Product Name	Species Reactivity	Application
CSB-PA666915ZA01PI	SNCA Antibody	Sus scrofa	ELISA, WB (ensure identification of antigen)

SNCA Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA021912ZA01MO	Snca Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

SNCA Proteins

SNCA Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP021912EQV CSB-EP021912EQV CSB-BP021912EQV CSB-MP021912EQV CSB-EP021912EQV-B	Recombinant Pan troglodytes Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Saguinus labiatus (Red-chested mustached tamarin)

Code	Product Name	Source
CSB-YP021912SVY CSB-EP021912SVY CSB-BP021912SVY CSB-MP021912SVY CSB-EP021912SVY-B	Recombinant Saguinus labiatus Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

Code	Product Name	Source
CSB-YP021912EQU CSB-EP021912EQU CSB-BP021912EQU CSB-MP021912EQU CSB-EP021912EQU-B	Recombinant Pan paniscus Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Erythrocebus patas (Red guenon) (Cercopithecus patas)

Code	Product Name	Source
CSB-YP021912EGU CSB-EP021912EGU CSB-BP021912EGU CSB-MP021912EGU CSB-EP021912EGU-B	Recombinant Erythrocebus patas Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP021912HU CSB-EP021912HU CSB-BP021912HU CSB-MP021912HU CSB-EP021912HU-B	Recombinant Human Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP021912HU	Recombinant Human Alpha-synuclein (SNCA)	Yeast
CSB-EP021912HU1	Recombinant Human Alpha-synuclein (SNCA), partial	E.coli
CSB-EP021912HU1e1	Recombinant Human Alpha-synuclein (SNCA), partial	E.coli
CSB-EP021912HU	Recombinant Human Alpha-synuclein (SNCA)	E.coli
CSB-MP021912HU	Recombinant Human Alpha-synuclein (SNCA) (Active)	Mammalian cell

SNCA Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP666915PI CSB-EP666915PI CSB-BP666915PI CSB-MP666915PI CSB-EP666915PI-B	Recombinant Pig Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP666915PI	Recombinant Pig Alpha-synuclein (SNCA)	E.coli
CSB-EP666915PIa0	Recombinant Pig Alpha-synuclein (SNCA)	E.coli
CSB-EP666915PIe1	Recombinant Pig Alpha-synuclein (SNCA)	E.coli

SNCA Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP021912PYX CSB-EP021912PYX CSB-BP021912PYX CSB-MP021912PYX CSB-EP021912PYX-B	Recombinant Pongo abelii Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP659673BO CSB-EP659673BO CSB-BP659673BO CSB-MP659673BO CSB-EP659673BO-B	Recombinant Bovine Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Lagothrix lagotricha (Brown woolly monkey) (Humboldt's woolly monkey)

Code	Product Name	Source
CSB-YP021912LNL CSB-EP021912LNL CSB-BP021912LNL CSB-MP021912LNL CSB-EP021912LNL-B	Recombinant Lagothrix lagotricha Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Gorilla gorilla gorilla (Western lowland gorilla)

Code	Product Name	Source
CSB-YP021912GGZ CSB-EP021912GGZ CSB-BP021912GGZ CSB-MP021912GGZ CSB-EP021912GGZ-B	Recombinant Gorilla gorilla gorilla Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP021912MOV	Recombinant Macaca fascicularis Alpha-synuclein (SNCA)	Yeast
CSB-EP021912MOV	Recombinant Macaca fascicularis Alpha-synuclein (SNCA)	E.coli
CSB-YP021912MOV CSB-EP021912MOV CSB-BP021912MOV CSB-MP021912MOV CSB-EP021912MOV-B	Recombinant Macaca fascicularis Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP021912MOV	Recombinant Macaca fascicularis Alpha-synuclein (SNCA)	Mammalian cell

SNCA Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP021912RA CSB-EP021912RA CSB-BP021912RA CSB-MP021912RA CSB-EP021912RA-B	Recombinant Rat Alpha-synuclein (Snca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP021912RA	Recombinant Rat Alpha-synuclein (Snca)	E.coli
CSB-EP021912RAe0	Recombinant Rat Alpha-synuclein (Snca)	E.coli

SNCA Proteins for Serinus canaria (Island canary) (Fringilla canaria)

Code	Product Name	Source
CSB-YP820922SYL CSB-EP820922SYL CSB-BP820922SYL CSB-MP820922SYL CSB-EP820922SYL-B	Recombinant Serinus canaria Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP021912MO CSB-EP021912MO CSB-BP021912MO CSB-MP021912MO CSB-EP021912MO-B	Recombinant Mouse Alpha-synuclein (Snca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA Proteins for Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey)

Code	Product Name	Source
CSB-YP021912AVF CSB-EP021912AVF CSB-BP021912AVF CSB-MP021912AVF CSB-EP021912AVF-B	Recombinant Ateles geoffroyi Alpha-synuclein (SNCA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SNCA ELISA Kit

SNCA ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-EL021912RA	Rat Alpha-synuclein(SNCA) ELISA kit	serum, plasma, tissue homogenates	0.156 ng/mL

SNCA ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E18033h	Human alpha-synuclein （SNCA）ELISA kit	serum, plasma	0.078 ng/mL

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