APP

The primary function of Amyloid Precursor Protein (APP) is to participate in the growth, development, and repair of nerve cells, as well as to influence synapse formation and plasticity. Its structure includes an N-terminal signal peptide, an extracellular domain composed of approximately 660 amino acids, and a C-terminal transmembrane and intracellular region. Under normal circumstances, APP is enzymatically cleaved through non-amyloidogenic pathways to produce metabolites with physiological functions. However, abnormal metabolic pathways may lead to the accumulation of β-amyloid, a major pathological feature of Alzheimer\'s disease. The signaling pathway of APP involves the participation of various enzymes, including α-, β-, and γ-secretases. The activity and regulation of these enzymes are crucial for the generation and clearance of APP metabolites. In research and clinical applications, APP and its metabolites are widely used in the diagnostic and therapeutic studies of Alzheimer\'s disease.

Validated Data

$\"CSB-RA994273A0HU$

Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HEK293 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Amyloid beta A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 35, 77, 79, 79, 81, 83, 85, 86, 73, 85 kDa
Observed band size: 100 kDa

$\"CSB-RA994273A0HU$

Immunofluorescence staining of Hela Cells with CSB-RA994273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

The following APP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

APP Antibodies

APP Proteins

APP ELISA Kits

APP Antibodies

APP Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA07174A0Rb	APP Antibody	Human	ELISA, IHC
CSB-PA07174B0Rb	APP Antibody, HRP conjugated	Human	ELISA
CSB-PA07174C0Rb	APP Antibody, FITC conjugated	Human
CSB-PA07174D0Rb	APP Antibody, Biotin conjugated	Human	ELISA
CSB-PA001950GA01HU	APP Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA001950OJ01HU	APP Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA001950NJ01HU	APP Antibody	Human	ELISA, WB
CSB-PA07179A0Rb	APP Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA07179B0Rb	APP Antibody, HRP conjugated	Human	ELISA
CSB-PA07179C0Rb	APP Antibody, FITC conjugated	Human
CSB-PA07179D0Rb	APP Antibody, Biotin conjugated	Human	ELISA
CSB-PA296382	Phospho-APP (Thr668) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA907645	APP (Ab-668) Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA212801	Phospho-APP (Thr743/668) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA000724	Phospho-APP (T743) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA000875	APP Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA891395	APP Antibody	Human	ELISA,IHC
CSB-PA123968	APP Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-MA0019501A0m	APP Monoclonal Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-EAP07174	APP Antibody Pair	Human,Rat,Mouse,Bovine,Pig,Goat	S-ELISA
CSB-RA994273A0HU	APP Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, IF
CSB-RA001950MA2HU	APP Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF
CSB-RA001950MA3HU	APP Recombinant Monoclonal Antibody	Human	ELISA, IF, FC
CSB-RA001950MB1HU	APP (GSK933776 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB2HU	APP (sabirnetug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB3HU	APP (AA001 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB4HU	APP (Aducanumab-avwa Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB5HU	APP (Anselamimab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB6HU	APP (CM-383 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB7HU	APP (Crenezumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB8HU	APP (Lecanemab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB9HU	APP (MEDI-1814 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB10HU	APP (PMN-310 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB11HU	APP (PRX-012 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB12HU	APP (Remternetug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA001950MB13HU	APP (SHR-1707 Biosimilar) Recombinant Monoclonal Antibody	Human

APP Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA580984XA01DLU	app Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

APP Proteins

APP Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-YP702442EQV CSB-EP702442EQV CSB-BP702442EQV CSB-MP702442EQV CSB-EP702442EQV-B	Recombinant Pan troglodytes Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF001950HU	Recombinant Human Amyloid-beta precursor protein（APP）	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP001950HU5	Recombinant Human Amyloid-beta precursor protein (APP), partial	Mammalian cell
CSB-MP001950HU4d9	Recombinant Human Amyloid-beta precursor protein (APP), partial	Mammalian cell

APP Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF001950PI	Recombinant Pig Amyloid beta A4 protein (APP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950PI1 CSB-EP001950PI1 CSB-BP001950PI1 CSB-MP001950PI1 CSB-EP001950PI1-B	Recombinant Pig Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Code	Product Name	Source
CSB-CF001950TKY	Recombinant Takifugu rubripes Amyloid beta A4 protein (app)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950TKY1 CSB-EP001950TKY1 CSB-BP001950TKY1 CSB-MP001950TKY1 CSB-EP001950TKY1-B	Recombinant Takifugu rubripes Amyloid beta A4 protein (app), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP001950MOW CSB-EP001950MOW CSB-BP001950MOW CSB-MP001950MOW CSB-EP001950MOW-B	Recombinant Macaca mulatta (Rhesus macaque) Amyloid beta A4 protein (APP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Saimiri sciureus (Common squirrel monkey)

Code	Product Name	Source
CSB-YP856771SWD CSB-EP856771SWD CSB-BP856771SWD CSB-MP856771SWD CSB-EP856771SWD-B	Recombinant Saimiri sciureus Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP631695BO CSB-EP631695BO CSB-BP631695BO CSB-MP631695BO CSB-EP631695BO-B	Recombinant Bovine Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Ursus maritimus (Polar bear) (Thalarctos maritimus)

Code	Product Name	Source
CSB-YP641824UAX CSB-EP641824UAX CSB-BP641824UAX CSB-MP641824UAX CSB-EP641824UAX-B	Recombinant Ursus maritimus Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP726646GU CSB-EP726646GU CSB-BP726646GU CSB-MP726646GU CSB-EP726646GU-B	Recombinant Guinea pig Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)

Code	Product Name	Source
CSB-CF001950TLV	Recombinant Tetraodon fluviatilis Amyloid beta A4 protein (app)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950TLV1 CSB-EP001950TLV1 CSB-BP001950TLV1 CSB-MP001950TLV1 CSB-EP001950TLV1-B	Recombinant Tetraodon fluviatilis Amyloid beta A4 protein (app), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP634665DO CSB-EP634665DO CSB-BP634665DO CSB-MP634665DO CSB-EP634665DO-B	Recombinant Dog Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP634684SH CSB-EP634684SH CSB-BP634684SH CSB-MP634684SH CSB-EP634684SH-B	Recombinant Sheep Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF001950RA	Recombinant Rat Amyloid beta A4 protein (App)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950RA1 CSB-EP001950RA1 CSB-BP001950RA1 CSB-MP001950RA1 CSB-EP001950RA1-B	Recombinant Rat Amyloid beta A4 protein (App), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-CF001950MOV	Recombinant Macaca fascicularis Amyloid beta A4 protein (APP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950MOV1 CSB-EP001950MOV1 CSB-BP001950MOV1 CSB-MP001950MOV1 CSB-EP001950MOV1-B	Recombinant Macaca fascicularis Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP635706RB CSB-EP635706RB CSB-BP635706RB CSB-MP635706RB CSB-EP635706RB-B	Recombinant Rabbit Amyloid beta A4 protein (APP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APP Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF001950MO	Recombinant Mouse Amyloid-beta precursor protein (App)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001950MO1 CSB-EP001950MO1 CSB-BP001950MO1 CSB-MP001950MO1 CSB-EP001950MO1-B	Recombinant Mouse Amyloid-beta precursor protein (App), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001950MOc7	Recombinant Mouse Amyloid beta A4 protein (App)	E.coli

APP ELISA Kit

APP ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E08299h	Human amyloid beta peptide 1-40,Aβ1-40 ELISA Kit	serum, tissue homogenates, cerebrospinal fluid (CSF)	31.25 pg/mL
CSB-E10684h	Human amyloid beta peptide 1-42,Aβ1-42 ELISA Kit	serum, plasma, tissue homogenates, cerebrospinal fluid (CSF)	0.078 ng/mL

APP ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-EL001950RA	Rat Amyloid beta A4 protein(APP) ELISA kit	serum, plasma, tissue homogenates	3.9 ng/mL
CSB-E08302r	Rat amyloid beta peptide 1-40,Aβ1-40 ELISA Kit	serum, plasma, tissue homogenates	0.156 pg/mL
CSB-E10786r	Rat amyloid beta peptide 1-42,Aβ1-42 ELISA Kit	serum, plasma, tissue homogenates	0.225 pg/mL

APP ELISA Kit for Monkey

Code	Product Name	Sample Types	Sensitivity
CSB-E14398Mk	Monkey amyloid beta peptide 1-42,Aβ1-42 ELISA Kit	serum, plasma	0.039 ng/mL

APP ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E08300m	Mouse amyloid beta peptide 1-40,Aβ1-40 ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL
CSB-E10787m	Mouse amyloid beta peptide 1-42,Aβ1-42 ELISA Kit	serum, plasma, tissue homogenates	3.9 pg/mL

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