Native Proteins

What are native proteins?

Native proteins are proteins in native state. The native state of a protein or nucleic acid is its properly folded and/or assembled form, which is operative and functional. The native state of a biomolecule may possess all four levels of biomolecular structure, with the secondary through quaternary structure being formed from weak interactions along the covalently-bonded backbone.

This is in contrast to the denatured state, in which these weak interactions are disrupted, leading to the loss of these forms of structure and retaining only the biomolecule's primary structure.

CUSABIO's native proteins

CUSABIO provides sensitive, high-resolution analysis of native proteins and protein complexes for molecular mass estimation and purity assessment.

Based on the blue native polyacrylamide gel electrophoresis technique, CUSABIO overcomes the limitations of traditional native electrophoresis by providing a near-neutral operating pH and detergent compatibility.

In addition, CUSABIO covers a variety of prepacked formats for native protein purification such as gravity columns, spin columns, 96-well plates, prepacked columns for use with automated chromatography systems.