Osteoporosis Research Tools: Quality Proteins, Antibodies & ELISA Kits

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World Osteoporosis Day is celebrated on 20 October each year and was officially established by the World Health Organisation (WHO) in 1998, with the aim of spreading awareness of osteoporosis and preventing and reducing the incidence of osteoporotic fractures. 2024 World Osteoporosis Day is themed ‘Say no to fragile bones’, encouraging people of all ages to pay attention to and protect their bone health.

Osteoporosis is a systemic bone disease caused by a variety of factors, mainly characterised by a decrease in bone density and quality, and damage to the bone microstructure, resulting in an increase in bone fragility and an increased susceptibility to fracture. Osteoporosis is mainly classified into two categories: primary and secondary. Primary osteoporosis is subdivided into postmenopausal osteoporosis (type I), senile osteoporosis (type II) and idiopathic osteoporosis. Osteoporosis is closely related to sarcopenia and the two often occur together, increasing the risk of falls and fractures.

The causes of osteoporosis are complex and varied, including genetic factors, changes in hormone levels, lifestyle habits and the effects of disease. According to statistics, there are currently about 200 million osteoporosis patients worldwide, and among people over 50 years old, the prevalence of osteoporosis in women is about 33%, while that in men is about 20%. With aging becoming more and more serious, the prevalence of osteoporosis tends to increase year by year. Therefore, it is crucial to raise the awareness of osteoporosis and strengthen the research and prevention of osteoporosis.

CUSABIO has long been committed to providing researchers with high-quality proteins, antibodies, ELISA kits and other tools for scientific research reagents, and has compiled a series of popular targets related to osteoporosis research and related reagent products listed below for your selection:

Popular Research Targets:

● Recombinant Proteins Relevant to Osteoporosis Research

Recombinant Human Interleukin-6 (IL6)
CSB-YP011664HU

Recombinant Human Tumor necrosis factor (TNF)
CSB-YP023955HU

Recombinant Human Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
CSB-MP023969HU

● Antibodies Relevant to Osteoporosis Research

CD19 Monoclonal Antibody
CSB-MA004888A0m

Tested Applications: ELISA, WB, IHC, IF, FC

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Tested Applications: ELISA, IF, FC

CD80 Recombinant Monoclonal Antibody
CSB-RA246383A0HU

Tested Applications: ELISA, WB, IHC, IP

Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody
CSB-RA011931A100phHU

Tested Applications: ELISA, WB, IHC, IP

● ELISA Kits Relevant to Osteoporosis Research

Rat TNF-α ELISA kit
CSB-E04640r

337 Citations

Mouse INS ELISA Kit
CSB-E05071m

117 Citations

Rat TNF-α ELISA kit
CSB-E11987r

455 Citations

Mouse TNF-α ELISA KIT
CSB-E04741m

381 Citations

Target	Product Name	Sample Types	Detection Range	Code
IL6	Human Interleukin 6,IL-6 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, urine	7.8 pg/mL-500 pg/mL	CSB-E04638h
IL6	Mouse Interleukin 6,IL-6 ELISA KIT		Request Information	CSB-E04639m
IL6	Rat Interleukin 6,IL-6 ELISA KIT		Request Information	CSB-E04640r
INS	Rat Insulin,INS ELISA KIT	serum, plasma, cell culture supernates	15.6 nIU/mL-1000 nIU/mL	CSB-E05070r
INS	Mouse Insulin,INS ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	15.6 nIU/mL-1000 nIU/mL	CSB-E05071m
NFKB1	Rat Nuclear factor-kappa B(NF-κB) ELISA KIT	serum, plasma, tissue homogenates	1.56 pg/mL-100 pg/mL	CSB-E13148r
TNF	Human Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	7.8 pg/mL-500 pg/mL	CSB-E04740h
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/ml-1000 pg/ml	CSB-E04741m
TNF	Rat TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E11987r

FAQ:

Q: What are the best targets to study osteoclast activity in osteoporosis?

Common osteoclast activity targets include ACP5 (TRAP), CTSK, NFATC1, and upstream regulators such as TNFSF11 (RANKL) and NFKB1.

Q: Which pathway is most central to osteoporosis drug and mechanism research?

The RANK/RANKL/OPG axis is one of the most central pathways because it directly controls osteoclast differentiation and bone resorption, making it a cornerstone for both mechanistic and therapeutic studies.

Q: How do IL-6 and TNF-α relate to osteoporosis experiments?

IL-6 and TNF-α are inflammatory cytokines that can shift bone remodeling toward resorption; they are commonly measured by ELISA and used as stimuli (recombinant proteins) to model inflammation-linked bone loss.

Q: What sample types are most used for osteoporosis ELISA biomarkers?

Most osteoporosis biomarker ELISA studies use serum/plasma, but cell culture supernatants and tissue homogenates are also common depending on the model and target.

Q: What screening guidance should researchers know when contextualizing osteoporosis studies?

In the US, the USPSTF (2025) recommends screening women aged 65+ and postmenopausal women <65 at increased risk; evidence is insufficient to recommend routine screening in men.

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