SOST

SOST, also known as Sclerostin or VBCH, is a secretory glycoprotein encoded by the SOST gene and part of the Cerberus/Dan BMP antagonist family. It is produced by bone cells and has anti-osteogenic effects, inhibiting bone formation by binding to LRP5/6 receptors and suppressing the Wnt signaling pathway. SOST is vital for bone homeostasis, density, and fracture healing, and its abnormal expression is linked to bone diseases such as osteoporosis and sclerosing bone disease. It is a potential therapeutic target for metabolic bone disease treatment and fracture repair promotion.

Validated Data

IHC image of CSB-RA858415MA1HU diluted at 1：100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA858415MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human Sclerostin(SOST) ELISA Kit(CSB-E13146h)

Validated Data

Code: CSB-E13146h

Size: 96T,5×96T,10×96T

Sensitivity: 7.8 pg/mL

Detection Range: 31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following SOST reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SOST Antibodies

SOST Proteins

SOST ELISA Kits

SOST Antibodies

SOST Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA859165ZA01RA	Sost Antibody	Rattus norvegicus	ELISA, WB (ensure identification of antigen)

SOST Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA858415ESR1HU	SOST Antibody	Human	ELISA, IHC
CSB-PA858415ESR2HU	SOST Antibody	Human	ELISA, WB, IHC
CSB-PA020254	SOST Antibody	Human	WB, ELISA
CSB-RA858415MA1HU	SOST Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA858415MB1HU	SOST (resugobart Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA858415MB2HU	SOST (Blosozumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA858415MB3HU	SOST (Romosozumab-AQQG Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA858415MB4HU	SOST (SAL-023 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA858415MB5HU	SOST (Setrusumab Biosimilar) Recombinant Monoclonal Antibody	Human

SOST Proteins

SOST Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP859165RA CSB-EP859165RA CSB-BP859165RA CSB-MP859165RA CSB-EP859165RA-B	Recombinant Rat Sclerostin (Sost)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP859165RA	Recombinant Rat Sclerostin (Sost)	E.coli
CSB-BP859165RA	Recombinant Rat Sclerostin (Sost)	Baculovirus
CSB-MP859165RA	Recombinant Rat Sclerostin (Sost)	Mammalian cell

SOST Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP858415HU CSB-EP858415HU CSB-BP858415HU CSB-MP858415HU CSB-EP858415HU-B	Recombinant Human Sclerostin (SOST)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP858415HU-B	Recombinant Human Sclerostin (SOST), Biotinylated	Mammalian cell
CSB-MP858415HUd7	Recombinant Human Sclerostin (SOST) (Active)	Mammalian cell

SOST Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP860205BO CSB-EP860205BO CSB-BP860205BO CSB-MP860205BO CSB-EP860205BO-B	Recombinant Bovine Sclerostin (SOST)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SOST Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP858168MO CSB-EP858168MO CSB-BP858168MO CSB-MP858168MO CSB-EP858168MO-B	Recombinant Mouse Sclerostin (Sost)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP858168MO	Recombinant Mouse Sclerostin (Sost)	Baculovirus
CSB-MP858168MO	Recombinant Mouse Sclerostin (Sost)	Mammalian cell

SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

Code	Product Name	Source
CSB-YP858374DSU CSB-EP858374DSU CSB-BP858374DSU CSB-MP858374DSU CSB-EP858374DSU-B	Recombinant Chlorocebus aethiops Sclerostin (SOST)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SOST ELISA Kit

SOST ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-EL022415RA	Rat Sclerostin(SOST) ELISA kit	serum, plasma, tissue homogenates	4.68 pg/mL

SOST ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E13146h	Human Sclerostin(SOST) ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily?Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

SOST

Popular Product: