PTK2

PTK2, also recognized as protein tyrosine kinase 2, FAK, FRNK, Fadk, FADK1, and p125FAK, is a non-receptor protein tyrosine kinase encoded by human genes. Ubiquitously expressed across various tissues, PTK2 is integral to cell adhesion, migration, and proliferation through its tyrosine kinase activity. It positively regulates cell population growth, the ubiquitin-dependent protein degradation process, and protein phosphorylation. PTK2's influence can be seen in vascular morphogenesis, neuron generation, and peptide-based tyrosine autophosphorylation, with its activity modulated by extracellular matrix, growth factors, and intracellular signaling molecules. Its dysfunction is associated with conditions such as leiomyomas, small cell lung cancers, and pulmonary hypertension, highlighting its potential as a drug development target.