Home
Product
Protein
Recombinant Proteins
Recombinant Xenopus laevis Focal adhesion kinase 1 (ptk2), partial

Recombinant Xenopus laevis Focal adhesion kinase 1 (ptk2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

ptk2

Purity

>85% (SDS-PAGE)

Target Names

ptk2

Uniprot NO.

Q91738

Alternative Names

ptk2; fak1Focal adhesion kinase 1; FADK 1; EC 2.7.10.2; Protein-tyrosine kinase 2; pp125FAK

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-1068

Target Protein Sequence

MAAAYLDPNL NHNPSTNAKS RLSTGMERSP GAIERVLRVF HYFESNNEPA TWSSNIRHGD ATDVRGIIQK IVDSHKVKNV ASYGLRLSHL HSEEVHWLHP DIGVSHIREK YEQSHPPEEW KYELRIRYLP KGFVNQFTED KPTLNFFYQQ VKNDYMSEIA DQVDQEIALK LGCLEIRRSY GEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI LKFFEILSPV YRYDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGSNP THLADFTQVQ TIQYSSSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VSGASESFII RPQKEGERAL PSIPKLANNE KHGVRPHAVS VSDEFSGDET DDYAEIIDEE DTYTMPSKSY GLDEAGDYEI QRDRIELGRC IGEGQFGDVH QGVYMSPENP AMAVAIKTCK NCTSDSVREK FLQEALTMRQ FDHPHIVKLI GVITENPVWI IMELCTLGEL RSFLQVRKYS LDLASLILYS YQLSTALAYL ESKRFVHRDI AARNVLVSSS DCVKLGDFGL SRYMEDSTYY KASKGKLPIK WMAPESINFR RFTSASDVWM FGVCMWEILM YGVKPFQGVK NNDVIGRIEN GERLPMPPNC PPTLYSLMTK CWAYDPSRRP RFTELKAQLS TILEEEKLQQ EERMRMESRR QVTVSWDSGG SDEAPPKPSR PGYPSPRSSE GFFPSPQHMM QPNHYQVSGF SVAHGIPSMS GNMYPGQASV LDHMDSWNHR TPDINMWQPS MEDSGPMDMR SLAQVLPTHL MEERLIRQQQ EMEEDQRWLE KEERFLKPDV RLSRGSVDHV DGNIQCPAGN QHIYQPVGKP DHVAPPKKPP RPGAPSHLGN LPAHNSPVDG YNEGVKPWRI QPQEISPPPT ANLDRTNDKV YENVTGLVKA VIEMSSRIQP APPEEYVPMV KGVGLALRTL LATVDETIPV LPASTHREIE MAQKLLNSDL AELINKMKLA QQYVMTSLQQ EYKKQMLTAA HALAVDAKNL LDVIDQARLK IISHSRPH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly.

Gene References into Functions

evidence that despite the fact that FAK is in the active, open conformation at CAs, its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells. PMID:27895123
FAK is required for external force-induced spindle reorientation, suggesting that FAK's involvement in this process stems from a role in the transduction of external forces to the cell cortex. PMID:25341507
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm. PMID:25127991
work identifies new roles for the FERM domain in the regulation of the dynamics of FAK on its signaling complexes in vivo and in vitro and identifies epiboly as the earliest developmental process in which FAK plays a crucial role during development PMID:24048589
These data suggest an important role for the FERM domain in the activation of FAK. PMID:22880041
FAK phosphorylation at Y861 is essential for lamellipodial protrusion induced by BDNF, while phosphorylation at Y925 controls the rate of point contact turnover. PMID:21940449
Data imply that FAK plays an essential role in chamber outgrowth and looping morphogenesis. PMID:20572259
FAK is required for proper topographic positioning of retinal axons along the anterior-posterior axis of the optic tectum in Xenopus and zebrafish, a guidance decision mediated in part by A-type ephrins. PMID:19890008

Hide All

Subcellular Location

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body. Note=Constituent of focal adhesions.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, FAK subfamily

Database Links

UNIGENE: Xl.6819

KEGG: xla:399286

Promotions