Recombinant Rat Focal adhesion kinase 1 (Ptk2), partial

1. Study demonstrated that MIF overexpression promotes the proliferation and migration of ASMCs by upregulating the activity of the ERK1/2 and FAK signaling pathways in these cells. PMID:28851074
2. thrombin stimulation of retinal pigment epithelium cell transformation and migration are regulated by FAK tyrosine phosphorylation. PMID:28445805
3. Stimulation of glucose transport in cardiomyocytes requires FAK activity prior to stimulation. The chronic reduction of FAK activity in cardiomyocytes exposed to free fatty acids contributes to the loss of glucose transport responsiveness to insulin or metabolic inhibition. PMID:27428469
4. In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c through an interaction with the FAK focal adhesion targeting (FAT) domain. PMID:27427476
5. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK signaling is inhibited. PMID:28360109
6. Pre-treatment of p38 inhibitor did not alter FAK activation. PMID:27704688
7. RACK1 promotes adhesion-mediated activation of ERK2 that in turn inhibits p190A-RhoGAP signaling by reducing the peripheral localization of p190A-RhoGAP. PMID:27212270
8. Hydrostatic mechanical force enhances the viability and decreases the apoptosis of condylar chondrocytes through integrin-FAK-ERK/PI3K pathway. PMID:27827993
9. The objectives of this study are to assess the localization of FAK phosphorylated at tyrosine residues in the sinus endothelial cells of rat spleen. PMID:26846226
10. Spinal cord injury results in diminished FAK signaling and is independent of ERK1/2 and Akt protein. PMID:26481700
11. MGF-C25E promotes tenocyte migration by increasing nuclear stiffness via the FAK-ERK1/2 signaling pathway. PMID:26742689
12. Synovial FAK expression was positive in collagen-induced arthritis rats, indicating that it played an important role in the pathogenesis of RA. DMARDs could reduce the FAK expression in synovial cells of CIA rats. PMID:26884826
13. Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle PMID:26294392
14. Dats show that CXCL10 chemokine treatment promoted the activation of p38 MAPK pathway through CXCR3 receptor signaling, thereby up-regulating focal adhesion kinase (FAK) activation and promoted cardiac microvascular endothelial cell migration. PMID:26835911
15. Fak protein plays role in cellular proliferation in tendon fibroblasts PMID:25898827
16. Inhibition of the early step of Focal adhesion kinase and proline-rich tyrosine kinase activation may comprise an important portion of the response expressed by modulation of some coupled signal transduction pathways. PMID:25708150
17. these results demonstrate that FAK and Rac1 signalings coordinately regulate the dynamics of FAs during VEGF-induced migration of MSCs in varying neural differentiation states. PMID:25820249
18. The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways participate in Perivascular adipocyte functions, which is activated by insulin-like growth factor 1(IGF-1) and inhibited by Gax. PMID:25280940
19. Correlation analysis revealed that integrin-alpha expression or FAK phosphorylation was positively associated with cytosolic CRT expression. PMID:24930861
20. LIPUS may affect the integrin-FAK-PI3K/Akt mechanochemical transduction pathway and alter ECM production by OA chondrocytes. PMID:24742749
21. both alphanu and beta1 integrins interfered with Abeta-induced neurotoxicity in hippocampal neurons and that this mechanism partially contributes to the activation of the Integrin-FAK signaling pathway. PMID:23755149
22. We established that phosphorylation of FAK Y397 with association with beta1 and beta3 integrins occurs with pressure-induced eutrophic remodeling. PMID:25300309
23. RACK1 scaffolds AGAP2 to FAK to regulate FAK activity and cell adhesion during the differentiation process. PMID:24056044
24. The key step for activating FAK's kinase-dependent functions--autophosphorylation of tyrosine-397--requires site-specific dimerization via association of its N-terminal FERM domain, stabilized by interaction between FERM and the C-terminal FAT domain. PMID:24480479
25. p-FAK-Tyr(407) has a role in affecting F-actin organization after perfluorooctanesulfonate-induced perturbation of male rat Sertoli cell blood-testis barrier function PMID:24169556
26. These findings illustrate a mechanistic pathway mediated by p-FAK-Tyr(397) that regulates spermatid adhesion at the apical ectoplasmic specialization in vivo. PMID:23880313
27. The results highlight that the expression of components for costameric attachment sites of myofibrils is under load- and fiber type-related control via FAK and its inhibitor FRNK. PMID:23904105
28. Cadmium affects focal adhesion kinase (FAK) in mesangial cells: involvement of CaMK-II and the actin cytoskeleton. PMID:23463649
29. neuregulin successfully improves axo-glial interaction by speeding Sc migration via the erbB2/3-FAK pathway PMID:23301073
30. Suggest that FAK acts as a central coordinator of integrin and growth factor-mediated S-phase entry by regulating Cdk2 in EGF-stimulated hepatocytes. PMID:23168795
31. critical role of sFRP1 in regulating spermiation via its effects on the FAK signaling and retention of nectin-3 adhesion complex at the apical ectoplasmic specialization PMID:23073828
32. The extracellular activation of matrix metalloproteinase 2 accelerated collagen-I synthesis in cardiac fibroblasts. Focal adhesion kinase phosphorylation (Tyr397) played a pivotal role in matrix metalloproteinase 2-stimulated collagen-I synthesis. PMID:22914642
33. Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil beta(2) integrin function. PMID:22778269
34. FAK-Tyr(407) phosphorylation promotes BTB integrity by strengthening the actin filament-based cytoskeleton. PMID:22797892
35. Angiotensin (Ang)II)-immunocomplexes in postnatal day-15 rat hindbrain contain mainly the 85 kDa fragment of FAK; besides, p125FAK associates to SHP-1. PMID:22120166
36. FAK silencing was protective against lung collagen deposition underscores the therapeutic potential of FAK targeting by small interfering RNA. PMID:22293597
37. FAK is activated in endotoxemia, playing a role in cardiac remodeling and in the impairment of cardiac function. PMID:21921830
38. Findings show that P-glycoprotein (Abcb1a and Abcb1b) structurally interacted with focal adhesion kinase (FAK), creating the occludin/ZO-1/FAK/P-glycoprotein regulatory complex. PMID:22106313
39. Salvia miltiorrhiza monomer IH764-3 can induce the expression of MMP-13 and inhibit the expression of TIMP-1 by down-regulating the expression of FAK. PMID:21180139
40. FAK undergoes S910 phosphorylation via PKCdelta and Src-dependent pathways that are important for cell spreading and sarcomere reorganization in cardiac hypertrophy. PMID:21937583
41. FRNK inhibits both FAK and proline-rich tyrosine kinase 2 (PYK2) in cultured vascular smooth muscle cells (VSMCs), and both kinases may be involved in VSMC invasion during vascular remodeling. PMID:21852560
42. Role of TINag in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pathway. PMID:21795690
43. Hypoxic preconditioning enhances the ability of mesenchymal stem cell migration; this effect is mediated through a regulatory role of Kv2.1 on FAK phosphorylation/activation. PMID:21562308
44. These results suggest that the integrin-associated tyrosine kinase FAK contributes to the regulation of the osteoblast differentiation in part through the regulation of Cbfa1 expression. PMID:21412826
45. These data show that FAK regulates HSC proliferation and induces the apoptosis of HSC via the caspase-3 and Bcl-2/Bax pathway. PMID:21569089
46. Rac1 through NADPH oxidase is part of the signaling pathway constituted by FAK, Rac1, and ERK that regulates focal adhesion disassembly during cell spreading. PMID:21660950
47. cell surface glycocalyx HSPGs, in the presence of integrin-mediated cell-matrix adhesions and cytoskeleton organization, sense interstitial flow and activate the FAK-ERK signaling axis, leading to upregulation of MMP expression and cell motility PMID:21246051
48. Phosphorylation of FAK and PYK2 is upregulated by elevated blood pressure but not by humoral factors in the rat aorta, demonstrating novel aspects of atherogenesis in hypertension. PMID:21068519
49. FRNK has independent signaling functions in vascular smooth muscle cells(decreased migratory capacity,decreased proliferation,etc.) PMID:20705914
50. FAK gene silencing suppresses adhesion and migration of hepatic stellate cells. PMID:19912685

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UNIGENE: Rn.2809

KEGG: rno:25614

STRING: 10116.ENSRNOP00000011219