MCL1

MCL1, a member of the Bcl-2 family, is an anti-apoptotic protein that curbs cell death by interacting with pro-apoptotic Bcl-2 proteins. Ubiquitous in its expression across various cell types, MCL1 is particularly influential in hematopoietic stem cells and neurons. Its function is centered around its role on the mitochondrial membrane, where it engages with other Bcl-2 family members at the BH3 binding site to govern cell survival and apoptosis. MCL1's expression and stability fluctuate under cellular stress, thereby impacting cell fate. Beyond apoptosis, MCL1 regulates non-apoptotic processes like the cell cycle, DNA damage response, autophagy, mitochondrial dynamics, and energy metabolism. Imbalances in MCL1 expression are tied to various diseases, especially in cancer, where its overexpression is associated with tumor development, poor prognosis, and resistance to treatment.

Popular Product:

MCL1 Antibody(CSB-PA003207)

Validated Data

Western Blot analysis of HepG2 cells using Mcl-1 Polyclonal Antibody

Western Blot analysis of NIH-3T3 Jurkat cells using Mcl-1 Polyclonal Antibody

The following MCL1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MCL1 Antibodies

MCL1 Proteins

MCL1 Antibodies

MCL1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA013588GA01HU	MCL1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA274877	MCL1 Antibody	Human	ELISA,WB
CSB-PA787977	MCL1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA003207	MCL1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA004991	MCL1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA010105	Phospho-MCL1 (S159) Antibody	Human,Mouse	WB, IF, ELISA
CSB-PA010107	MCL1 Antibody	Human,Mouse,Monkey	WB, ELISA
CSB-PA256752	MCL1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA438059	MCL1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA03829A0Rb	MCL1 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA03829B0Rb	MCL1 Antibody, HRP conjugated	Human	ELISA
CSB-PA03829C0Rb	MCL1 Antibody, FITC conjugated	Human
CSB-PA03829D0Rb	MCL1 Antibody, Biotin conjugated	Human	ELISA

MCL1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA874875XA01SXV	mcl1 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

MCL1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA013588HD01MO	Mcl1 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA013588HA01MO	Mcl1 Antibody	Mouse	ELISA

MCL1 Proteins

MCL1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF810233DO	Recombinant Dog Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP810233DO1 CSB-EP810233DO1 CSB-BP810233DO1 CSB-MP810233DO1 CSB-EP810233DO1-B	Recombinant Dog Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)

Code	Product Name	Source
CSB-YP385863RIJ CSB-EP385863RIJ CSB-BP385863RIJ CSB-MP385863RIJ CSB-EP385863RIJ-B	Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

Code	Product Name	Source
CSB-YP522144RLD CSB-EP522144RLD CSB-BP522144RLD CSB-MP522144RLD CSB-EP522144RLD-B	Recombinant Rhodobacter capsulatus Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)

Code	Product Name	Source
CSB-YP394443RLG CSB-EP394443RLG CSB-BP394443RLG CSB-MP394443RLG CSB-EP394443RLG-B	Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-CF768742CA	Recombinant Cat Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP768742CA1 CSB-EP768742CA1 CSB-BP768742CA1 CSB-MP768742CA1 CSB-EP768742CA1-B	Recombinant Cat Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP768742HU CSB-EP768742HU CSB-BP768742HU CSB-MP768742HU CSB-EP768742HU-B	Recombinant Human Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP768742HU	Recombinant Human Induced myeloid leukemia cell differentiation protein Mcl-1(MCL1), partial	E.coli

MCL1 Proteins for Rhodobacter capsulatus (Rhodopseudomonas capsulata)

Code	Product Name	Source
CSB-YP466974RLC CSB-EP466974RLC CSB-BP466974RLC CSB-MP466974RLC CSB-EP466974RLC-B	Recombinant Rhodobacter capsulatus Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-YP874875SXV CSB-EP874875SXV CSB-BP874875SXV CSB-MP874875SXV CSB-EP874875SXV-B	Recombinant Schizosaccharomyces pombe Minichromosome loss protein 1 (mcl1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-EP013588MO	Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1), partial	E.coli
CSB-YP013588MO CSB-EP013588MO CSB-BP013588MO CSB-MP013588MO CSB-EP013588MO-B	Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF013588MO	Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Rhodobacter sphaeroides (strain KD131 / KCTC 12085)

Code	Product Name	Source
CSB-YP495428RLH CSB-EP495428RLH CSB-BP495428RLH CSB-MP495428RLH CSB-EP495428RLH-B	Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

Code	Product Name	Source
CSB-YP667039RLF CSB-EP667039RLF CSB-BP667039RLF CSB-MP667039RLF CSB-EP667039RLF-B	Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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