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Recombinant Schizosaccharomyces pombe Minichromosome loss protein 1 (mcl1), partial

Recombinant Schizosaccharomyces pombe Minichromosome loss protein 1 (mcl1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

mcl1

Purity

>85% (SDS-PAGE)

Target Names

mcl1

Uniprot NO.

Q9C107

Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Source

Yeast

Expression Region

1-815

Target Protein Sequence

MAGNRLVPRY AHTDGLTRLA YTRDGKFLLT VGSNQVIRKF QVGSDEEPDS IDNHQDPITG IAVAENYFCT CSEDATVCVY PIDSPTEHTL LARTTLPIRD VAYSVDGNWI AIASDETAVK VVSSTDSSQI FSLRPAKASN KHVTYSPNGN FLAVSSCNGI LYFYDTQTRE LIKFLTNTIA SLEAESEICS KAAWHPKNGT FAVASTDHFV SVISPDDWLP LYKLLPKENH SGVTDISWSS NGMYIAASFK KGGILIWDTQ SHEVVVELPY STVVALAWQP FENVLSFTTN QGILYSCPDV IPKSILKEEN DPTKPLTSSK SKNRTSKELD DLFGSDDEQS QNVNDLDGNS ANEENEFINH DGLDSSLDLD GDSYMVDEND LNLAKKRKQK ALIDRTTTIE NGSSKRRLLQ ASIHKPVHTG STPWQGNRRY LCLNLVGFIW TVQQDAEHNT ITVEFHDETT HRKYHFVDDQ KFEMACLDHE GALYASPATE SSPGVIYYKA HVDWSRKSEW AMALPMENES PVTISLSSSV VLVCTSAGYV RVFSRQGFPI SIHRSKHLPF VACSSFQDTI ITIANDGLSS DGNSRLVYSI EDISRDEMLQ TGDGVALPPQ GTLESVFFSD VGDPYIYDST GVLLVLMHWR IPGQAKWIPV LDTNELERRK SRQESYWPVT VADNQFHCIL LKGASRYPYF PRPMFTEFDF RIPCNTNNPD ASTSVPVLEE LQLRNKLFLT LLEDSIGDGD VTEDEKISIA RLEANIDKAL LQLIQKACLE ERIERVYELT KTLRRTTSIA AAQKIALHHS LTNVAEKIGN LLSNV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Has a role in regulating DNA replication complexes. Acts as a regulator of post DNA replication initiation. Associates with chromatin during G1 and S phases of mitosis. Required for the transcriptional repression of the outer repeats of the centromeric region. Acts as a polymerase alpha replication accessory factor and is important for S-phase DNA damage survival. Plays a role in lagging-strand synthesis and Ozaki fragment processing, in addition to DNA repair.

Gene References into Functions

Mcl1p is a dynamic component of the polymerase alpha complex during replication and is important for the replication stress response in fission yeast PMID:15643072
results suggest that Mcl1 and Pol alpha are required for propagation of centromere chromatin structures during DNA replication PMID:18493607

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Subcellular Location

Nucleus. Chromosome.

Database Links

KEGG: spo:SPAPB1E7.02c

STRING: 4896.SPAPB1E7.02c.1

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