Recombinant Bovine Interleukin-2 receptor subunit alpha (IL2RA)

CSB-CF011649BO
Size:
20μg
20μg100μg
US$4395
Quantity:
Express system: in vitro E.coli expression system
Species: Bos taurus (Bovine)
Tag Info: N-terminal 10xHis-tagged
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Product Details

Target Names
IL2RA
Uniprot NO.
Species
Bos taurus (Bovine)
Source
in vitro E.coli expression system
Expression Region
22-275
Target Protein Sequence
EACHDDPPSLRNAMFKVFRYEVGTMINCDCKTGFRRVSAVMRCVGDSSHSAWENRCFCNSTSPAKNQVKQVTPAPEEHREKKHTDAQNQTQPPEEADLPGHCEEPPPWEHEREPLKRVYHFTLGQTVHYQCAQGFRALQTSPAESTCMMINGELRWTRPRLKCIREGEHGQASDDAEPQESTEAPPGSGTFLPTRMAGTTNFQKPTDEIATLDTFIFTTEYQIAVAGCTLLLASILLLSCLTWQRKWKKNRRTI
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged
Troubleshooting and FAQs
Datasheet & COA
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Description

Customer Reviews and Q&A

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Target Background

Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
Gene References into Functions
  1. Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains. PMID:25456194
  2. Increase of CD25 expression on bovine neutrophils correlates with mastitis severity in post-partum and early lactating dairy cows. PMID:25106916
  3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells. PMID:25001909
  4. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells. PMID:23059841
  5. determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle. PMID:12496181
  6. Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor. PMID:12906107
  7. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population PMID:18928784

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Database Links

UNIGENE: Bt.3941

KEGG: bta:281861

STRING: 9913.ENSBTAP00000027834

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