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Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA)

Recombinant Cat Interleukin-2 receptor subunit alpha (IL2RA)

Code: CSB-CF011649CA

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Size:

20μg100μg

US$4395

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Express system: in vitro E.coli expression system

Species: Felis catus (Cat) (Felis silvestris catus)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

IL2RA

Uniprot NO.

P41690

Species

Felis catus (Cat) (Felis silvestris catus)

Source

in vitro E.coli expression system

Expression Region

22-275

Target Protein Sequence

ELCDENPPDIQHATFKALTYKTGTMLNCECKKGFRRISNGSAFMLCAGNSSHSSWENQCRCISTSPRATDGQIIPKPEEQKGKSPMGMQSQMQPTDQVNLPGHCREPPPWEHEDSRRIYHFVVGQTVHYQCMQGFRALKRGPAKSVCKTTCGKATWTQPRLQCLSERSDGWFPDDEEPQASTDAALGSDTSCPSITASTTDFQRHTEVAMTTESFVFTTEYQIAVAGCVLLLISIVLLSGLTWQRRWRKSRRTI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

Gene References into Functions

CD4+ CD25+ T cells showed constitutive and IL-2-responsive transactivation important for Feline Immunodeficiency Virus (FIV) replication. PMID:15795282
Results suggest that CD4(+)CD25(+) and CD4(+)CD25(-) T cells have different activation requirements which can be modulated by both viral and cytokine stimuli to reach threshold activation levels in order to harbor a productive FIV infection. PMID:15840520

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Database Links

KEGG: fca:493953

STRING: 9685.ENSFCAP00000005380

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