CXCL3

CXCL3, also known as C-X-C motif chemokine 3, is a small cytokine belonging to the CXC chemokine family. It is also commonly called GRO3 and MIP-2γ. CXCL3 binds to the CXCR2 receptor. Through this interaction, it recruits and activates neutrophils at sites of inflammation. It is involved in the NF-κB signaling pathway, which regulates immune and inflammatory responses.
Dysregulation of CXCL3 has been associated with various diseases, including cancer, where it can promote tumor growth and metastasis by facilitating angiogenesis. In drug development, targeting CXCL3 and its receptor CXCR2 is being explored as a potential therapeutic strategy to treat inflammatory and cancer - related conditions.