CXCL3 Antibody

Code: CSB-PA009037

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: IHC, ELISA

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Target Background

Product Details

Uniprot NO.

P19876

Target Names

CXCL3

Alternative Names

C-X-C motif chemokine 3 antibody; C-X-C motif chemokine ligand 3 antibody; Chemokine (C X C motif) ligand 3 antibody; Chemokine (CXC motif) ligand 3 antibody; Cinc 2 antibody; CINC 2b antibody; Cinc2 antibody; CINC2b antibody; CXCL 3 antibody; Cxcl3 antibody; CXCL3_HUMAN antibody; Cytokine induced neutrophil chemoattractant 2 antibody; Dcip1 antibody; Dendritic cell inflammatory protein 1 antibody; Gm1960 antibody; GRO protein gamma antibody; GRO-gamma antibody; GRO-gamma(1-73) antibody; GRO-gamma(5-73) antibody; GRO3 antibody; GRO3 oncogene antibody; GROG antibody; Growth regulated protein gamma antibody; Growth-regulated protein gamma antibody; Macrophage inflammatory protein 2 beta precursor antibody; Macrophage inflammatory protein 2-beta antibody; Melanoma growth stimulatory activity gamma antibody; Member 3 antibody; MGSA gamma antibody; MIP 2b antibody; MIP2-beta antibody; MIP2B antibody; SCYB3 antibody; Small inducible cytokine subfamily B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human GROγ.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Gene References into Functions

CXCL3 exerts its carcinogenic potential by directly and/or indirectly regulating the downstream signaling pathways and the expression of transcription factors in PCa. PMID:29524043
Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression. PMID:27255419
Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID:26837773
results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy PMID:24605943
CXCL3 displays antimicrobial activity against E. coli and S. aureus. PMID:12949249
secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells. PMID:23589610
Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells. PMID:23023221
demonstrates, for the first time, that BIRC3 (anti-apoptotic protein), COL3A1 (matrix protein synthesis), and CXCL3 (chemokine) were up-regulated in the thrombin-stimulated human umbilical vein endothelial cells PMID:16356540
GRO-gamma is a promising candidate for Th2-associated glomerular permeability factor in minimal change disease. PMID:17389786
Inhibition of ERK phosphorylation decreased expression of GRO3. PMID:17466952
Report gonadotropin-releasing hormone-regulated CXCL3 expression in human placentation. PMID:19369450
propose that chemokines belonging to the CXC family could play an important role in the etiology of tendon xanthoma (TX), with CXCL3 being a possible biological marker of onset and development of TX PMID:19448742
overexpression of CXCL13 in the intestine during inflammatory conditions favors mobilization of B cells and of LTi and NK cells with immunomodulatory and reparative functions. PMID:19741597