CLDN18

CLDN18, or tight junction protein 18, Claudin-18.CLDN18 is encoded by the human CLDN18 gene, which is located on chromosome 3 in the 3q28 region.
CLDN18 is a tight junction protein that is mainly involved in forming intercellular tight junctions, regulating cellular bypass permeability and maintaining the integrity of the epithelial cell layer.
Its mechanism of action involves interaction with other tight junction proteins in the cell membrane to form stable tight junction structures that control the flow of molecules and ions between cells.
CLDN18 is highly expressed in alveolar epithelial cells and gastric epithelial cells and is essential for lung and gastric development and function. Aberrant expression of CLDN18 is associated with a variety of diseases, including lung and gastric cancers. Especially in lung cancer, CLDN18 expression is associated with tumor aggressiveness and poor prognosis, and is a potential diagnostic marker and therapeutic target.

Validated Data

CSB-MP4304MOV is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant Antibody (CSB-RA005498A1HU), the EC₅₀ is 2.806-3.641 ng/ml.

The purity of VLPs was greater than 90% as determined by SEC-HPLC

Recombinant Mouse Claudin-18.2 (Cldn18.2)-VLPs (Active)(CSB-MP005498MO(F3))

Validated Data

CSB-MP005498MO(F3) is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Cldn18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005498A1HU), the EC₅₀ is 6.115-11.01 ng/mL.

Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active)(CSB-MP005498HU(A5))

Validated Data

Western Blot
CSB-MP005498HU(A5) is detected by Mouse anti-6*His monoclonal antibody.The three bands respectively correspond to monomer, Homodimer, Homotrimer

Activity
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC₅₀ is 5.225-9.256 ng/ml.

The presence of VLP-like structures was confirmed by TEM

Western Blot
CSB-MP005498HU(A5) is detected by Anti-Claudin 18 Antibody.The two bands respectively correspond to monomer, Homodimer

CLDN18 Recombinant Monoclonal Antibody(CSB-RA005498A2HU)

Validated Data

Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2µg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

The Binding Activity of Human CLDN18.2 with Anti-CLDN18 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/mL can bind Anti-CLDN18 recombinant antibody, the EC₅₀ is 2.947-8.782 ng/mL.

The following CLDN18 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CLDN18 Antibodies

CLDN18 Proteins

CLDN18 Antibodies

CLDN18 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005498GA01HU	CLDN18 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA005498ESR1HU	CLDN18 Antibody	Human	ELISA, WB, IHC
CSB-PA005498ESR2HU	CLDN18 Antibody	Human, Rat	ELISA, WB, IHC
CSB-PA005498LA01HU	CLDN18 Antibody	Human	ELISA, IHC, IF
CSB-PA005498LC01HU	CLDN18 Antibody, FITC conjugated	Human
CSB-PA005498LB01HU	CLDN18 Antibody, HRP conjugated	Human	ELISA
CSB-MA148581	CLDN18 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA005498A2HU	CLDN18 Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA005498A1HU	Claudin-18.2 Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA005498A3HU	CLDN18 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, FC
CSB-RA005498MB1HU	CLDN18 (Zolbetuximab Biosimilar) Recombinant Monoclonal Antibody	Human

CLDN18 Proteins

CLDN18 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF005498HU	Recombinant Human Claudin-18 (CLDN18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP005498HU1 CSB-EP005498HU1 CSB-BP005498HU1 CSB-MP005498HU1 CSB-EP005498HU1-B	Recombinant Human Claudin-18 (CLDN18), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005498HU2	Recombinant Human Claudin-18 (CLDN18), partial	E.coli
CSB-EP005498HU2b0	Recombinant Human Claudin-18 (CLDN18), partial	E.coli

CLDN18 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF610823BO	Recombinant Bovine Claudin-18 (CLDN18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP610823BO1 CSB-EP610823BO1 CSB-BP610823BO1 CSB-MP610823BO1 CSB-EP610823BO1-B	Recombinant Bovine Claudin-18 (CLDN18), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CLDN18 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF005498MO	Recombinant Mouse Claudin-18 (Cldn18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP005498MO1 CSB-EP005498MO1 CSB-BP005498MO1 CSB-MP005498MO1 CSB-EP005498MO1-B	Recombinant Mouse Claudin-18 (Cldn18), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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CLDN18

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