Recombinant Mouse Claudin-18 (Cldn18), partial

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cldn18

Uniprot NO.

P56857

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Gene References into Functions

The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness PMID:27215490
The claudin-18 knockout mice exhibited decreased P2X7 mRNA transcript abundance as measured by mRNA expression microarray PMID:27663455
CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice. PMID:24787463
Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties. PMID:24588076
we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling PMID:23299504
Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area. PMID:14698084
Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation PMID:22437732
Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis. PMID:22079592
Increased expression of claudin-18 is associated with ulcerative colitis. PMID:18831034