Recombinant Mouse Claudin-18 (Cldn18)

1. The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness PMID:27215490
2. The claudin-18 knockout mice exhibited decreased P2X7 mRNA transcript abundance as measured by mRNA expression microarray PMID:27663455
3. CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice. PMID:24787463
4. Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties. PMID:24588076
5. we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling PMID:23299504
6. Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area. PMID:14698084
7. Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation PMID:22437732
8. Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis. PMID:22079592
9. Increased expression of claudin-18 is associated with ulcerative colitis. PMID:18831034

Show More

Hide All

UNIGENE: Mm.386784

KEGG: mmu:56492

STRING: 10090.ENSMUSP00000035048