TSLP

Thymic Stromal Lymphopoietin (TSLP), also known as a thymic stroma-derived cytokine, is a protein encoded by the TSLP gene. It can act as a pleiotropic cytokine, activating T cells and dendritic cells. TSLP is involved in the JAK - STAT signaling pathway, which is crucial for immune regulation.
TSLP is associated with various diseases, including allergic asthma and atopic dermatitis. Given its role in these diseases, TSLP has become an important target in drug development. Several TSLP - targeting biologics are currently in different stages of clinical trials, aiming to alleviate symptoms and improve patient outcomes.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Loaded Cynomolgus TSLP(R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody(CSB-RA025141MA1HU), with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime).

Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TSLP(R127A,R130S) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC₅₀ is 45.77-53.37 ng/mL.

Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) (Active)(CSB-MP025141HU(M))

Validated Data

Activity
Measured by its binding ability in a functional ELISA. Immobilized human TSLP(R127A,R130A) at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC₅₀ is 52.55-58.67 ng/mL.

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of TSLP was greater than 95% as determined by SEC-HPLC

TSLP Recombinant Monoclonal Antibody(CSB-RA025141MA1HU)

Validated Data

IHC image of CSB-RA025141MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human thymic stromal lymphopoietin,TSLP ELISA Kit(CSB-E09316h)

Validated Data

Code: CSB-E09316h

Size: 96T,5×96T,10×96T

Sensitivity: 0.078 ng/ml

Detection Range: 0.312 ng/ml-20 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following TSLP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TSLP Antibodies

TSLP Proteins

TSLP ELISA Kits

TSLP Antibodies

TSLP Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA025141GA01HU	TSLP Antibody	Human	ELISA,IHC
CSB-PA218260	TSLP Antibody	Human	ELISA,WB
CSB-PA025141LA01HU	TSLP Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA025141LC01HU	TSLP Antibody, FITC conjugated	Human
CSB-PA025141LD01HU	TSLP Antibody, Biotin conjugated	Human	ELISA
CSB-RA025141A1HU	TSLP Recombinant Monoclonal Antibody	Human	ELISA
CSB-RA025141MA2HU	TSLP Recombinant Monoclonal Antibody	Human, Macaca fascicularis	ELISA
CSB-RA025141MA1HU	TSLP Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA025141MB1HU	TSLP (CN 115210258 A Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB2HU	TSLP (tezepelumab Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB3HU	TSLP (APG333 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB4HU	TSLP (Bosakitug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB5HU	TSLP (CM-326 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB6HU	TSLP (GB-0895 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB7HU	TSLP (HBM-9378 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB8HU	TSLP (MG-014 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB9HU	TSLP (QX-008N Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB10HU	TSLP (SHR-1905 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB11HU	TSLP (Solrikitug Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB12HU	TSLP (STSA-1201 Biosimilar) Recombinant Monoclonal Antibody	Human
CSB-RA025141MB13HU	TSLP (Tavo-101 Biosimilar) Recombinant Monoclonal Antibody	Human

TSLP Proteins

TSLP Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-MP5042MOV(M)	Recombinant Macaca fascicularis Thymic stromal lymphopoietin (TSLP) (R127A,R130S) (Active)	Mammalian cell
CSB-YP5042MOV	Recombinant Macaca fascicularis Thymic stromal lymphopoietin (TSLP)	Yeast
CSB-MP5042MOVd7	Recombinant Macaca fascicularis Thymic stromal lymphopoietin (TSLP) (Active)	Mammalian cell
CSB-MP5042MOVd7-B	Recombinant Macaca fascicularis Thymic stromal lymphopoietin (TSLP), Biotinylated (Active)	Mammalian cell

TSLP Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-EP4184RB	Recombinant Rabbit Thymic stromal lymphopoietin (TSLP), partial	E.coli

TSLP Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP025141HU CSB-EP025141HU CSB-BP025141HU CSB-MP025141HU CSB-EP025141HU-B	Recombinant Human Thymic stromal lymphopoietin (TSLP)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP002121HU	Recombinant Human Thymic stromal lymphopoietin protein (TSLP) (Active)	E.coli
CSB-MP025141HU	Recombinant Human Thymic stromal lymphopoietin (TSLP)	Mammalian cell
CSB-EP025141HU	Recombinant Human Thymic stromal lymphopoietin (TSLP)	E.coli
CSB-MP025141HUh8(M)	Recombinant Human Thymic stromal lymphopoietin (TSLP)(R127A,R130A)	Mammalian cell
CSB-MP025141HU(M)	Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) (Active)	Mammalian cell
CSB-MP025141HUh7	Recombinant Human Thymic stromal lymphopoietin (TSLP) (Active)	Mammalian cell

TSLP Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP025141MO CSB-EP025141MO CSB-BP025141MO CSB-MP025141MO CSB-EP025141MO-B	Recombinant Mouse Thymic stromal lymphopoietin (Tslp)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli