DLL3

DLL3, a member of the Delta/Serrate/Lag-2 (DSL) family, serves as a Notch ligand. DLL3 is mainly found on the surface of neuroendocrine tumor cells, without expression in normal adult tissues. Its function involves interacting with Notch receptors, typically serving as an inhibitory ligand that prevents the activation of the Notch signaling pathway upon binding to these receptors. This interaction influences the proliferation, differentiation, and apoptosis of tumor cells. In particular, DLL3 expression is notably significant in small cell lung cancer (SCLC), where elevated levels correlate strongly with tumor genesis and progression, marking it as a promising therapeutic target for SCLC treatment. The aberrant expression of DLL3 is associated with the development of various neuroendocrine tumors. This association underscores DLL3's significance as both a biomarker and a potential therapeutic target in the treatment of cancers.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DLL3 Recombinant Monoclonal Antibody(CSB-RA882142A1HU)

Validated Data

Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2µl/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC₅₀ is 1.625-2.702 ng/mL.

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC₅₀ is 1.102-1.707 ng/mL.

The purity of DLL3 was greater than 95% as determined by SEC-HPLC

Human Delta-like protein 3(DLL3) ELISA kit(CSB-EL006948HU)

Validated Data

Code: CSB-EL006948HU

Size: 96T,5×96T,10×96T

Sensitivity: 4.68 pg/mL

Detection Range: 18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following DLL3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

DLL3 Antibodies

DLL3 Proteins

DLL3 ELISA Kits

DLL3 Antibodies

DLL3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA882142LA01HU	DLL3 Antibody	Human	ELISA, IHC
CSB-PA882142LB01HU	DLL3 Antibody, HRP conjugated	Human	ELISA
CSB-PA882142LC01HU	DLL3 Antibody, FITC conjugated	Human
CSB-PA882142LD01HU	DLL3 Antibody, Biotin conjugated	Human	ELISA
CSB-RA882142A1HU	DLL3 Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA882142MA2HU	DLL3 Recombinant Monoclonal Antibody	Human	ELISA, FC
CSB-RA882142MB1HU	DLL3 (Rovalpituzumab Biosimilar) Recombinant Monoclonal Antibody	Human

DLL3 Proteins

DLL3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-MP3536MOV	Recombinant Macaca fascicularis Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell

DLL3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF006948RA	Recombinant Rat Delta-like protein 3 (Dll3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP006948RA1 CSB-EP006948RA1 CSB-BP006948RA1 CSB-MP006948RA1 CSB-EP006948RA1-B	Recombinant Rat Delta-like protein 3 (Dll3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DLL3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial	Yeast
CSB-EP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial	E.coli
CSB-YP882142HU CSB-EP882142HU CSB-BP882142HU CSB-MP882142HU CSB-EP882142HU-B	Recombinant Human Delta-like protein 3 (DLL3)，partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882142HU1	Recombinant Human Delta-like protein 3 (DLL3), partial	E.coli
CSB-MP882142HU	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-EP882142HU2-B	Recombinant Human Delta-like protein 3 (DLL3), partial,Biotinylated	E.coli
CSB-MP882142HU2	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU2d7	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU3	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-MP882142HU3d7	Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	Mammalian cell
CSB-EP7979HUg5	Recombinant Human Delta like canonical Notch ligand 3 (DLL3)	E.coli

DLL3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF006948MO	Recombinant Mouse Delta-like protein 3 (Dll3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP006948MO1 CSB-EP006948MO1 CSB-BP006948MO1 CSB-MP006948MO1 CSB-EP006948MO1-B	Recombinant Mouse Delta-like protein 3 (Dll3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP006948MO1r13	Recombinant Mouse Delta-like protein 3 (Dll3), partial (Active)	Mammalian cell

DLL3 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP346574XBE CSB-EP346574XBE CSB-BP346574XBE CSB-MP346574XBE CSB-EP346574XBE-B	Recombinant Xenopus laevis Homeobox protein DLL-3 (dll3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

DLL3 ELISA Kit

DLL3 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL006948HU	Human Delta-like protein 3(DLL3) ELISA kit	serum, plasma, tissue homogenates	4.68 pg/mL

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DLL3

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