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Recombinant Mouse Delta-like protein 3 (Dll3), partial

Recombinant Mouse Delta-like protein 3 (Dll3), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Dll3

Uniprot NO.

O88516

Alternative Names

Dll3; Delta-like protein 3; Drosophila Delta homolog 3; Delta3; M-Delta-3

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Regarding your protein CSB-EP006948MO1, could you please advise whether the proteins expressed by this and the 3 other hosts are secreted proteins, in inclusion bodies, or other?

Regarding your question, as we haven't expressed these proteins before, we are not sure if they will form inclusion bodies during the expression,however, even if they form inclusion bodies, we will conduct inclusion body renaturation to ensure that all of the proteins provided are soluble form.

I am most concerned about the high-cysteine content of this protein, because I need the disulfide bonds to be properly formed. I would like to know if any of the eukaryotic versions of this protein are “secreted” – could you please advise on this?

Thanks for your inquiry. Your concern is reasonable. This protein is easy to form inclusion bodies. In this case, we recommend you to choose Yeast expressed protein or Mammalian cell expressed protein. What we provide is the secreted protein.

Target Background

Function(From Uniprot)

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Gene References into Functions

Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review. PMID:27655002
Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer. PMID:28007595
O-fucosylation of DLL3 is required for its function during somitogenesis. PMID:25856312
Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis. PMID:22095884
Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch. PMID:21151194
Dll3 targets Notch1 for lysosomal degradation preventing Notch1 from undergoing post-translational processing. PMID:21147753
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. PMID:11923214
DLL3 knockout mice have segmentation and neural defects PMID:12141422
spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway. PMID:17600782
study reports that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2; Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2 PMID:17823936
study shows that genetic interactions between Notch1 and Dll3 result in vertebral segmental defects similar to those seen in congenital scoliosis; craniofacial anomalies not previously observed in Dll3 homozygous animals were identified PMID:17849441
Dll3 are expressed in the developing mouse eye and in retinal progenitor cell. PMID:19191219
a complex interplay of E-box binding proteins spatially and temporally regulate Dll3 levels during neural tube development. PMID:19389376
Data show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenesis. PMID:19686682