CD79A, also referred to as MB-1, is the alpha chain of the B-cell antigen receptor complex. This 47 kDa membrane glycoprotein pairs with CD79B to form the heterodimeric B cell receptor (BCR), which is crucial for B cell signaling and subsequent activation, apoptosis, or allergic responses. CD79A's primary function is to facilitate signal transduction in conjunction with CD79B; when an antigen binds to the BCR, the CD79A/CD79B heterodimer transmits activation signals that trigger B cell proliferation, differentiation, and antibody production. The cytoplasmic region of CD79A contains the immune receptor tyrosine activating motif (ITAM), a critical structure for signal transduction. CD79A plays a vital role in B cell function, including antigen recognition, activation, proliferation, and differentiation. Additionally, its expression is linked to the development of certain B-cell tumors, such as B-cell acute lymphoblastic leukemia (B-ALL). Therefore, CD79A is a significant target for research and therapeutic interventions in B cell biology and related diseases.
Popular
Product:
CD79A Recombinant Monoclonal Antibody(CSB-RA004957MA1HU)
Validated Data
The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 1.521-1.700 ng/mL.
The Binding Activity of Human CD79A&CD79B with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 8.012-9.339 ng/mL.
The purity of CD79A was greater than 95% as determined by SEC-HPLC
The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1p6) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 14.44-16.80 ng/mL.
Untransfected HEK-293T cells (green line) and transfected Human CD79A&CD79B HEK-293T stable cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected HEK-293T cells (green line) and transfected Human CD79A HEK-293T pool cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The following CD79A
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
