Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a)

1. BCR activation is accompanied by asymmetric conformational changes, possibly promoting the binding of Igalpha and Igbeta to differently localized signaling complexes PMID:24244439
2. CD79a myeloid cells showed enhanced ability to promote primary tumor growth and metastasis. PMID:24146823
3. Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells. PMID:24129701
4. Data show that the B cell antigen receptor (BCR) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR signaling pathway leading to activation of Syk, indicating crosstalk between the two receptors. PMID:23453634
5. The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection. PMID:21688146
6. endocytosed BCR sequentially regulates MAPK and Akt signaling pathways from intracellular compartments PMID:21964606
7. Data indicate that both the Igalpha and the Igbeta cytoplasmic domains alone are sufficient for trafficking to lysosomal compartments, and are unaffected by mutation of 4 amino acid residues within their respective ITAMs. PMID:20837062
8. Arginine 198 in the tail of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. Methylation negatively regulates the calcium and PI-3 kinase pathways of the BCR, promoting signals leading to B cell differentiation. PMID:20231378
9. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways PMID:11909947
10. IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. PMID:12006975
11. The VHDJH recombination process at the IgH locus and the survival of pro-B cells that carry these rearrangements do not depend on the expression of Ig-alpha molecules. PMID:12097390
12. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. PMID:12165508
13. Data show that expression of endogenous mb-1 transcripts correlates most closely with early-B-cell factor (EBF) expression and negatively with Id1, an inhibitor of E2A protein function, linking regulation of the mb-1 gene with EBF and E2A. PMID:12446773
14. Retrovirally expressed human Pax-5 protein activates endogenous early B-cell-specific mb-1 genes in mouse plasmacytoma cells, but only when the promoter is hypomethylated. PMID:12612069
15. Ig-alpha immunoreceptor tyrosine-based activation motif (ITAM) tyrosines (Y182 and Y193) are necessary for efficient pre-B cell differentiation. PMID:17163454
16. MHC II structural requirements for mediation of cell death signaling in a murine B cell lymphoma with Igalpha/beta PMID:18194817

Show More

Hide All

UNIGENE: Mm.1355

KEGG: mmu:12518

STRING: 10090.ENSMUSP00000003469