Recombinant Chicken Growth/differentiation factor 8 (MSTN)

1. Studied three chicken lines to identify the polymorphism in the coding region of the myostatin gene. PMID:27565871
2. The c.234G>A substitution in the myostatin (MSTN) gene negatively regulates the expression of MSTN in the Bian chicken and that it may be used in marker-assisted selection to accelerate the chicken breeding process. PMID:26513577
3. These data imply that alternative splicing isoforms of MSTN could negatively regulate pro-myostatin processing in muscle cells and prevent MSTN-mediated inhibition of myogenesis in chickens, turkeys, and quail. PMID:26354750
4. The body weight gain and breast muscle yield of light chicks were improved by increasing dietary Methionine levels probably through alterations of MSTN transcription and phosphorylation of mTOR and FoxO4. PMID:25437444
5. Low daily feed intake did not alter the trend in myostatin (MSTN) mRNA expression levels in either line, but significantly changed the peak values. Myogenin (MYOG) mRNA expression varied by line and over time, with a delay in the Lean line. PMID:24397509
6. In conclusion, these studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation. PMID:24570433
7. results suggested that the E-boxes in the chicken MSTN promoter region are involved in the regulation of myostatin expression and the polymorphisms in E3 and E4 altered the expression of myostatin. PMID:23670598
8. Myostatin haplogroups had significant effect on chicken body weight at 28, 42, and 49 days of age in the PB-1 line and days 14 and 49 in the CB line. In the IWI line the myostatin gene was polymorphic with no significant association with growth traits. PMID:23472013
9. Association analysis showed that the G2283A were significantly associated with reproduction traits. Bian chickens of the GG genotype had a greater age at first egg than those of the GA and AA genotypes. PMID:22870873
10. G2283A mutation in the myostatin gene has the potential to be a genetic marker for body weight traits in the female Bian chicken. PMID:20931358
11. This study indicates that the autocrine action of myostatin is partially enhanced by IGF-I through increasing its expression. PMID:19466527
12. Myostatin (MSTN) is sensitive to nutrient supply in hatching chicks, and fasting reduced MSTN mRNA levels in muscles of older chickens. PMID:14757186
13. single nucleotide polymorphisms of the myostatin gene play an important role in controlling skeletal muscle growth and differentiation, and also may be involved in regulation of adipose growth PMID:15382673
14. myostatin was expressed in the ventral myotomal region of mature somites, confirming the importance of myostatin in skeletal muscle tissue formation during embryogenesis PMID:16180589
15. Myostatin is an important signalling molecule responsible for imposing quiescence upon myogenic precursors during embryonic and foetal development. PMID:16425219
16. These results suggest that deficiency of GDF-8 delays cell differentiation and causes great alterations in the cellular morphology of chicken embryonic myotubes. PMID:16611734
17. the ontogeny of myostatin expression coincided with myogenesis of chicken PMID:16870219
18. Role of endogenous myostatin in autocrine regulation of muscle growth. PMID:17362950
19. Two polymorphic sites in the first exon 1 of MSTN gene in 180 Wenling grass-chicken including 3 lines were studied by PCR-RFLP method,and its genetic effects on carcass traits were researched. PMID:17548330
20. GDF-8 is ubiquitously expressed in various tissues of chicken embryos including testis and ovary through the stage of embryogenesis. PMID:17707668
21. The present experiment was designed for studying the expression profiles of myostatin mRNA in the chicken liver, heart, brain, and intestine during their morphogenesis, using real-time PCR. PMID:18037460
22. results indicate that myostatin and peroxisome-proliferator-activator-gamma-coactivator-1alpha(PGC-1alpha) expression in skeletal muscle rapidly change in response acute cold PMID:19427158
23. These results suggest that the acute regulation of PGC-1alpha and myostatin gene expression in leg muscles is required for chicks to acquire cold tolerance up to 7 days of age. PMID:19798921

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UNIGENE: Gga.560

KEGG: gga:373964

STRING: 9031.ENSGALP00000039571