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Recombinant Goat Growth/differentiation factor 8 (MSTN)

Recombinant Goat Growth/differentiation factor 8 (MSTN)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

MSTN

Purity

>85% (SDS-PAGE)

Target Names

MSTN

Uniprot NO.

Q6T5B8

Alternative Names

MSTN; GDF8Growth/differentiation factor 8; GDF-8; Myostatin

Species

Capra hircus (Goat)

Source

Yeast

Expression Region

267-375

Target Protein Sequence

DFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA PKRYKANYCS GECEFLFLQK YPHTHLVHQA NPKGSAGPCC TPTKMSPINM LYFNGKEQII YGKIPGMVVD RCGCS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts specifically as a negative regulator of skeletal muscle growth.

Gene References into Functions

MSTN knockdown caused an upregulation (p < 0.05) of MyoD and downregulation (p < 0.01) of MYf5 and FST expression. Moreover, we report up to approximately four fold (p < 0.001) enhanced proliferation in myoblasts after four days of culture. The anti-MSTN shRNA demonstrated in the present study could be used for the production of transgenic goats to increase the muscle mass. PMID:28358646
The reduced expression of myostatin gene was achieved and measured in clonal fibroblast cells by real-time PCR. PMID:26234434
This study also suggests the importance of siRNA-mediated knockdown of MSTN as a potential alternative to increase muscle mass and meat production. PMID:24254256
A study of the MSTN 5' upstream region and investigation of 5'UTR TTTTA deletion was carried out in seven different Indian goat breeds. An 1181 bp fragment of 5' upstream region of MSTN gene was PCR amplified, cloned, and sequenced. PMID:24299184
myostatin plays a negative role in regulating the expression of adipogenesis related genes in goat fetal fibroblasts. PMID:23604693
Polymorphisms of myostatin gene as markers associated with growth in Boer goats. PMID:21710248