MMP14

MMP14, or matrix metalloproteinase 14, is a membrane-type enzyme encoded by the human MMP14 gene and situated on chromosome 12. It primarily functions on the cell surface, utilizing its zinc ion binding site in the catalytic active region to catalyze reactions. MMP14 is instrumental in the activation of other MMPs, including MMP2, which are vital for the extracellular matrix remodeling and significantly impact tumor invasion and metastasis. This enzyme is not only involved in physiological processes such as tissue development and reproduction but also plays a role in pathological conditions like arthritis and cancer spread. The upregulation of MMP14 in many tumors is closely associated with poor prognosis, particularly in pancreatic and liver cancers. Furthermore, MMP14 contributes to the modulation of immune responses and inflammation.