Recombinant Rat Matrix metalloproteinase-14 (Mmp14), partial

1. The results suggest that MMP-14 is involved in proliferative diabetic retinopathy angiogenesis. PMID:29853773
2. expression of MMP-14 was different between cardiac isografts and allografts. MMP-14 could interact with CD44 in allografts. PMID:27712978
3. that MT1-MMP contributes to intestinal development, particularly to villi morphogenesis PMID:27640084
4. Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease. PMID:26620678
5. The MMP-1 is present in several brain areas in normal conditions at a detectable level, and its expression increases after kainate-induced seizures. PMID:23683405
6. Hepatic stellate cells acquired dependence on collagen for their growth during the transition from quiescent to active states. The intramolecular RGD motifs of collagen were exposed by cleavage with their own membrane type 1 matrix metalloproteinase. PMID:24867951
7. High MT1-MMP is associated with glomerulosclerosis in diabetic nephropathy. PMID:21414971
8. The MT1-MMP expression was widespread in the dental follicle. PMID:21909755
9. MT1-MMP was found in the cytoplasm of cells that may remodel the gubernaculum for eversion. It provides the collagenolysis necessary for migration through the inguinal fat pad. Disruption of these processes may cause cryptorchidism. PMID:22152881
10. MT1-MMP plays a crucial role in RAGE-activated NADPH oxidase-dependent signaling pathways. PMID:20945382
11. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. PMID:20683769
12. Data suggest that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth. PMID:20857180
13. Addition of follicle stimulating hormone to Sertoli cells increased the MMP-14 mRNA level three-fold, implicating a role in spermatogenesis. PMID:11928819
14. may play a role in extracellular matrix degradation during periodontitis PMID:12747454
15. cross-talk between the hemopexin domain of MT1-MMP and adjacent cell surface molecules is responsible for outside-in signaling. PMID:14729674
16. MT1-MMP is not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage. PMID:15044209
17. expression patterns indicate that MT1-MMP may play key role in uterine postpartum involution and subsequent functional regenerative processes PMID:16740171
18. The differentiation-dependent co-expression of Mmp14 with EMMPRIN in the enamel organ and in odontoblasts indicates that EMMPRIN takes part in the induction of proteolytic enzymes in the rat tooth germ. PMID:17684756
19. These data indicate that Indian hedgehog promotes pancreatic stellate cell migration by enhancing brane-type 1 matrix metalloproteinase localization on the plasma membrane but is negatively regulated by Gli-1. PMID:18286538
20. MT1-MMP has multiple functions and is implicated in multiple steps of the differentiation process, acting to regulate homeostasis of the osteogenic differentiation. PMID:19027888

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UNIGENE: Rn.10371

KEGG: rno:81707

STRING: 10116.ENSRNOP00000049168