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Recombinant Rabbit Matrix metalloproteinase-14 (MMP14), partial

Recombinant Rabbit Matrix metalloproteinase-14 (MMP14), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

MMP14

Purity

>85% (SDS-PAGE)

Target Names

MMP14

Uniprot NO.

Q95220

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.

Gene References into Functions

MT1-MMP plays a crucial role in RAGE-activated NADPH oxidase-dependent signaling pathways. PMID:20945382
MMP-1 was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation. PMID:18597092

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Subcellular Location

Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm.

Protein Families

Peptidase M10A family

Database Links

UNIGENE: Ocu.6250

KEGG: ocu:100009598

STRING: 9986.ENSOCUP00000008835

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