IL17A

IL17A, interleukin 17A, alias CTLA8, is mainly produced by activated T cells, especially Th17 cells, and IL-17A is also produced by CD8+ T cells, γδ T cells, natural killer T cells (NKT), monocytes and neutrophils.
The mechanism of action of IL-17A involves binding to the IL-17 receptor family, particularly to IL-17RA with high affinity, activating downstream signaling pathways and promoting the production of inflammatory factors.
IL-17A plays a key role in host defense against a wide range of bacterial and fungal pathogens and is also involved in allergic and autoimmune responses. It induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases, which are involved in inflammatory and tissue repair processes and have been associated with the development of several autoimmune diseases and tumors.