ICAM1, also known as Intercellular Adhesion Molecule 1, is a well - studied protein with aliases like CD54. It plays a crucial role in the immune response by mediating cell - cell adhesion and leukocyte recruitment. It acts by binding to integrins on the surface of leukocytes, facilitating their migration to sites of inflammation. This process is involved in the MAPK and NF - κB signaling pathways.
ICAM1 is associated with various diseases including asthma, atherosclerosis, and some autoimmune disorders. In drug development, efforts are underway to design antagonists that can block its interaction with integrins. These antagonists hold promise for treating inflammatory and autoimmune conditions by reducing excessive immune cell infiltration.
Popular
Product:
ICAM1 Recombinant Monoclonal Antibody(CSB-RA162789A0HU)
Validated Data
IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA162789A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following ICAM1
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
ICAM1 Proteins
ICAM1 Proteins for Pan troglodytes (Chimpanzee)
ICAM1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
ICAM1 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
ICAM1 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
ICAM1 Proteins for Rattus norvegicus (Rat)
ICAM1 Proteins for Homo sapiens (Human)
ICAM1 Proteins for Macaca mulatta (Rhesus macaque)
ICAM1 Proteins for Bos taurus (Bovine)
ICAM1 Proteins for Mus musculus (Mouse)
