QVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Gene References into Functions
The results suggest that ICAM-1 may play a critical role in bladder inflammation in severe non-bacterial cystitis and may be used as a novel therapeutic target in non-bacterial bladder inflammation such as bladder pain syndrome/interstitial cystitis.PMID:27782122
Pro-atherogenic effects of aldosterone are mediated by increased ICAM-1 expression, through transcriptional regulation by endothelial MR.PMID:28089144
Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression.PMID:27525872
MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.PMID:27889748
The results of this study showed that ICAM-1 up regulation in both sexs rats with aneurysmal subarachnoid hemorrhage.PMID:26923576
intercellular adhesion molecule-1 has a role in the restructuring of the blood-testis barrier during spermatogenesis [review]PMID:26419651
ICAM-1 induction in vascular endothelium and leukocyte adhesion to vascular endothelium is decreased in NSun2 knock-out rats.PMID:26838785
ICAM-1 protein expression in the yellow wine (0.5% -1.5%) groups were significantly different. Yellow wine decreases ICAM-1 protein expression.PMID:26853250
PilE4:ICAM-1 interaction unfolded here may provide a new perspective on molecules involved in the adhesion of extracellular form of Francisella to endothelial cells.PMID:25769821
findings reveal a novel function of ICAM-1 in osteogenesis and suggest a new molecular target to improve bone regeneration and repair in inflammatory microenvironments.PMID:24702024
analysis of the role of Txnip, ICAM-1, and NOX2 expression in diabetes-induced endothelial dysfunctions with curcuminPMID:25054130
No correlation was found between ICAM1 levels and microvascular or macrovascular dysfunction in adjuvant-induced arthritis.PMID:25708190
Hesperetin-7-O-glucuronide decreased hydrogen peroxide-induced intracellular adhesion molecule-1 and monocyte chemoattractant protein-1 mRNA expression in rat aortic endothelial cells.PMID:23831969
Exogenously applied caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules.PMID:24043249
Data illustrate the existence of a unique mechanism in the mammalian testis where ICAM-1 can either positively or negatively regulate blood-testis barrier function.PMID:22976294
Simvastatin attenuates lung injury induced by ischemia-reperfusion of the hind limb in rats by suppressing the activation of NF-kappaB p65 and subsequent accumulation of neutrophils mediated by ICAM-1.PMID:21764683
Intercellular adhesion molecule-1 blockade attenuates ischemia/reperfusion injury (IRI) via reduction of leukocyte-endothelial interactions and improvement of capillary perfusion emphasizing its central role during IRI in pancreas transplantationPMID:22617707
Infection with Japanese encephalitis virus elicits elevated production of intercellular adhesion molecule-1 in brain.PMID:22845610
Repeated high + Gz exposures could injure cardiovascular endothelium of rat and increase ICAM-1 expression.PMID:21180061
renal expression increased in spontaneously hypertensive rats with renal damagePMID:22681549
Melatonin protected lung tissue from acute injury by scavenging free radicals and inhibiting the expression of ICAM-1.PMID:21158154
Hydrogen sulfide reduced the expressions of NFKB and ICAM1 in pulmonary tissue of rats with acute lung injury.PMID:22333058
A cholesterol diet plays a role in the expression of ICAM-1 but not in that of VCAM-1 in the rat aorta. The expression of ICAM-1 in the aorta regresses after the withdrawal of a cholesterol-rich diet.PMID:22351665
The freezing/thawing of vascular endothelial cells can elicit an increase in ICAM-1 expression on the cell surface.PMID:21162227
Vaspin inhibits TNF-alpha-induced expression of ICAM-1 via preventing the reactive oxygen species generation and subsequent activation of NF-kappaB and PKCtheta;.PMID:21683791
Data suggest that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions.PMID:21860531
ICAM1 up-regulation at the time of implantation is under the control of progesterone, and is not dependent on cytokine release from the blastocyst or in semenPMID:21448983
Proteolytic cleavage of the extracellular domain of ICAM-1 and accumulation in kidney glomeruli may play a role in the renal involvement of inflammation.PMID:21464573
a signaling pathway involving aldose reductase, JNK, IKK, and NF-kappaB is required for ICAM-1 induction in ECs exposed to BFT, and may be involved in the leukocyte-adhesion cascade following infection with ETBF.PMID:21724992
Aging may upregulate lung MCP-1 and ICAM-1 expressions and enhance LPS-induced increments of MCP-1 and ICAM-1 expressions to exacerbate pulmonary inflammation in rats.PMID:20335145
Intercellular adhesion molecule 1 (ICAM-1) and E-selectin was down-regulated exclusively in mesenchymal stem cells /mycophenolate mofetil -treated grafts, indicating that MSC together with MMF interfere with endothelial activationPMID:21194567
Activation of the cholinergic anti-inflammatory pathway can protect the lung against ventilator-induced lung injury by suppressing IL-8 and ICAM-1 expression.PMID:20663304
in the early phase of acute oral mucosal graft-versus-host disease,the induction of ICAM-1 expression on keratinocytes leads to the migration of CD8+ cells into the epitheliumPMID:21472687
Isoflurane up-regulated the expression of ICAM-1 in LPS-induced rat lung microvascular endothelial cells but sevoflurane and desflurane down-regulated expression.PMID:20936719
Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain.PMID:21071702
The expression of ICAM-1 and MUC5AC in lung tissue were both significantly higher in allergic rhinitis than that in control group.PMID:16229173
Salvia significantly reduces the expressions of NF-kappaB and ICAM-1 in ischemia-reperfusion hepatic tissue.PMID:20979835
during localized inflammatory pain, peripheral sensory and sympathetic nerve fibers augment the expression of vascular endothelial ICAM-1PMID:20600813
Baicalin can decrease the contents of TNF-alpha and sICAM-1, and alleviate inflammation in lung tissues of rats infected with Pneumocystis carinii.PMID:19856505
By up-regulating the expression of ICAM-1 and MMP-9 protein and mRNA in pulmonary vascular wall, cigarette smoke exposure mediated pulmonary vascular inflammation and remodeling.PMID:20079284
Transferring NF-kappa B p65 antisense oligonucleotides into hepatic stellate cells weakened the expression of ICAM-1 and TGF beta 1 mRNA and the protein induced by TNF alpha.PMID:18983774
ICAM-1 mRNA analysis may be useful for estimation of early wound age because of its time-related expression after contusion in skin and muscle.PMID:19241963
Elevated expression of ET-1, iNOS, COX-2, and ICAM-1 occurred in the cortex of middle cerebral artery occlusion (MCAO) model rats.PMID:20083630
Curcumin can ameliorate cerebral pathological changes in the event of ischemia-reperfusion injury by suppressing the expressions of NF-kappaB and ICAM-1.PMID:19726347
Leptin induces an inflammatory phenotype in lean Wistar rats that includes increased production of ICAM-1, MCP-1, and IL-6 by hepatocytesPMID:20150963
The expression of ICAM-1 mRNA peaked at 6 h in skeletal muscle after contusion.PMID:19697769