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CD96 (US20200199227A1 Biosimilar) Recombinant Monoclonal Antibody

CD96 (US20200199227A1 Biosimilar) Recombinant Monoclonal Antibody

Code: CSB-RA004971MB1HU

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Size:

100ug

100ug500ug1mg5mg10mg50mg100mg200mg

US$199

Quantity:

Species Reactivity: Human

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Target Background

Product Details

Uniprot NO.

P40200

Target Names

CD96

Alternative Names

CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96

Species Reactivity

Human

Immunogen

Recombinant Human CD96 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Datasheet & COA

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Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to the reference antibody described in US20200199227A1, specifically targeting CD96, an immunoglobulin superfamily member expressed on T cells and natural killer (NK) cells. CD96 functions as an immune checkpoint receptor that binds to CD155 (PVR) on target cells, delivering inhibitory signals that dampen cellular cytotoxicity and immune responses. This interaction plays a critical role in regulating NK cell and T cell activity within the tumor microenvironment, making CD96 an important mediator of immune evasion in various malignancies including melanoma, lung cancer, and hematological cancers.

The reference antibody represents a therapeutic candidate developed for immune checkpoint blockade strategies aimed at enhancing anti-tumor immunity. This biosimilar antibody serves as a valuable research tool for investigating CD96-mediated immune regulation, studying NK cell and T cell exhaustion mechanisms, and exploring combination immunotherapy approaches. It enables researchers to examine CD96 blockade effects in preclinical models and to elucidate the molecular mechanisms underlying immune checkpoint inhibition in oncology research.

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Target Background

Function(From Uniprot)

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

Gene References into Functions

Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID:29531070
Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID:27620276
CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID:26642704
In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID:24751333
down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID:23272144
CD96 could serve as a target structure for effector cell-mediated lysis. PMID:22879978
The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID:21729528
CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID:15034010
CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID:17576927
CD96-driven adhesion to CD155 may be crucial in developmental processes PMID:19056733

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.

Database Links

HGNC: 16892

UNIGENE: Hs.142023

KEGG: hsa:10225

STRING: 9606.ENSP00000283285

OMIM: 211750

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