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Recombinant Human T-cell surface protein tactile (CD96)

Recombinant Human T-cell surface protein tactile (CD96)

Code: CSB-CF004971HU

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20μg100μg

US$6715

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

CD96

Uniprot NO.

P40200

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Expression Region

22-585

Target Protein Sequence

VWEKTVNTEENVYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVENSSTDSWVLLSKGIKEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGMSWPVIVAALLFCCMILFGLGVRKWCQYQKEIMERPPPFKPPPPPIKYTCIQEPNESDLPYHEMETL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

Gene References into Functions

Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID:29531070
Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID:27620276
CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID:26642704
In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID:24751333
down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID:23272144
CD96 could serve as a target structure for effector cell-mediated lysis. PMID:22879978
The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID:21729528
CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID:15034010
CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID:17576927
CD96-driven adhesion to CD155 may be crucial in developmental processes PMID:19056733

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.

Database Links

HGNC: 16892

UNIGENE: Hs.142023

KEGG: hsa:10225

STRING: 9606.ENSP00000283285

OMIM: 211750

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