ULBP1 Recombinant Monoclonal Antibody

Code: CSB-RA446786A0HU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

Q9BZM6

Target Names

ULBP1

Alternative Names

UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human ULBP1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

13C8

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
All lanes: ULBP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 36-50 kDa

Description

The ULBP1 recombinant monoclonal antibody was generated using the synthesized peptide derived from human ULBP1 protein as the immunogen. To obtain the DNA sequence of the SLC39A6 monoclonal antibody, the cDNA was sequenced and the gene was cloned into a plasmid vector. The plasmid vector containing the ULBP1 monoclonal antibody gene was then transfected into a host cell using an appropriate transfection method. The resulting ULBP1 recombinant monoclonal antibody underwent affinity-chromatography purification and was tested for specificity in an ELISA and WB applications. It can react with human ULBP1 protein.

ULBP1 is a glycoprotein that functions as a ligand for the NKG2D receptor, a type of immune cell receptor that is primarily expressed on the surface of natural killer (NK) cells and a subset of T cells. ULBP1 is expressed on the surface of stressed or infected cells and plays an important role in the immune system's ability to recognize and eliminate infected or abnormal cells. When binding to NKG2D on the surface of NK cells, ULBP1 triggers a series of events that ultimately result in the activation of the NK cell and the destruction of the target cell.

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Target Background

Function(From Uniprot)

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene References into Functions

we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID:26992229
ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID:26565589
expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID:24911793
recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID:21756848
recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID:21464092
Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID:20220060
These results identify Mult1 as a target for the MARCH family of E3 ligases PMID:20870941
As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID:18394338
Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID:19500498
ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID:11777960
The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID:12847260
ULBP1 is a human ligand of the NKG2D receptor PMID:16901903
The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID:19414815

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.

Protein Families

MHC class I family

Tissue Specificity

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Database Links

HGNC: 14893

UNIGENE: Hs.653255

KEGG: hsa:80329

STRING: 9606.ENSP00000229708

OMIM: 605697

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