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Recombinant Human Keratin, type I cytoskeletal 15 (KRT15)

Recombinant Human Keratin, type I cytoskeletal 15 (KRT15)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

KRT15

Uniprot NO.

P19012

Alternative Names

AI528832; CK 15; CK-15; CK15; Cytokeratin-15; Cytokeratin15; K15; K1C15_HUMAN; K1CO; Ka15; Keratin 15 ; Keratin 15 basic; Keratin 15 beta; Keratin; Keratin complex 1 acidic gene 15; Keratin type I cytoskeletal 15; Keratin-15; Keratin15; KRT 15; Krt1-15; KRT15; KRTB; KRTL15; Type I cytoskeletal 15; Type I keratin Ka15

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-456

Target Protein Sequence

MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

Underexpression of CK15 is associated with Esophageal Squamous Cell Carcinomas. PMID:27797221
Cytokeratin 15 is upregulated in a subset of urothelial cell carcinomas. PMID:24260555
K15 is expressed variably in both oral squamous cell carcinoma and squamous intraepithelial neoplasm PMID:22648550
both expanded limbal NCs and HUVEC rejoined with LEPC to form spheres to upregulate expression of DeltaNp63alpha, CK15, and CEBPdelta, the former but not the latter abolished expression of CK12 keratin. PMID:22538425
Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID:21574054
CK15 highlights BZ cells in normal human follicles PMID:21251039
Physiological concentrations of thyroid hormones T3 and T4 enhance keratin 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. PMID:20656376
Report expression of stem-cell markers cytokeratin 15 and nestin in primary adnexal neoplasms. PMID:20700038
Results identify the regulators of keratin 15 promoter activity and their binding sites. PMID:15060141
Cytokeratin 15 expression pattern is useful in terms of distinguishing trichoepithelioma from basal cell carcinoma. PMID:18789069
marker of the hair follicle stem cells; diminished during scarring in alopecia and discoid lupus erythematosus PMID:19162247
Identification of a subset of breast carcinomas characterized by expression of CK15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease is reported. PMID:19383306
KRT15 is a Gli1-responsive gene in human skin keratinocytes PMID:20050020
KRT15 mRNA is selectively expressed in human hair follicle stem cells, while KRT15 protein is not. PMID:20050020

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Protein Families

Intermediate filament family

Tissue Specificity

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Exp

Database Links

HGNC: 6421

UNIGENE: Hs.654570

KEGG: hsa:3866

STRING: 9606.ENSP00000254043

OMIM: 148030

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