Abbreviation
Recombinant Human PTH protein, partial (Active)
Purity
>97% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Activity
Fully biologically active when compared to standard. The specific activity is determined by UMR106 cell/cAMP method, corresponding to a specific activity of >1.0x104 IU/mg.
Research Area
Signal Transduction
Alternative Names
hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Parathyroid hormone; Prepro PTH; Preproparathyroid hormone; PTH; PTH1; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHY_HUMAN
Species
Homo sapiens (Human)
Expression Region
38-65aa
Target Protein Sequence
LMHNLGKHLN SMERVEWLRK KLQDVHNF
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Tag Info
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Lead Time
5-10 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Datasheet & COA
Please contact us to get it.
Description
This tag-free fragment spanning residues 38–65 of human PTH delivers validated bioactivity exceeding 1.0 × 10⁴ IU/mg as measured by cAMP induction in UMR106 cells, confirming robust PTH1R engagement suitable for receptor binding assays, competition studies, and downstream cAMP signaling experiments. The partial sequence corresponds to a functionally critical region of parathyroid hormone, enabling focused structure-function investigations of receptor interaction domains without interference from fusion tags. Endotoxin levels below 1.0 EU/μg combined with purity greater than 97% by SDS-PAGE satisfy the criteria typically required for in vivo pharmacology models of calcium homeostasis and metabolic bone disease, as well as for use as a calibration standard in immunoassays. This E. coli-expressed protein provides a suitable basis for antibody development campaigns targeting the mid-region epitope of mature PTH.
