TRAF6

TRAF6, or TNF receptor-associated factor 6, is a key adaptor protein in innate and adaptive immunity. As an E3 ubiquitin ligase, it mediates lysine-63-linked polyubiquitination to activate downstream signaling. It participates in TLR/IL-1R pathways, triggering NF-κB and MAPK activation, crucial for inflammation and immune responses.
Dysregulated TRAF6 is linked to autoimmune diseases like rheumatoid arthritis and cancers such as multiple myeloma. Preclinical studies target its ubiquitin ligase activity with small-molecule inhibitors, showing promise in modulating inflammatory disorders and malignancies, though clinical translation remains ongoing.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TRAF6 Recombinant Monoclonal Antibody(CSB-RA037392A0HU)

Validated Data

TRAF6 Recombinant Monoclonal Antibody

TRAF6 Antibody(CSB-PA024154LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA024154LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA024154LA01HU at dilution of 1:100

Immunofluorescence staining of Hela cells with CSB-PA024154LA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human tumor necrosis factor receptor-associated factor 6,TRAF6 ELISA kit(CSB-E14078h)

Validated Data

Human tumor necrosis factor receptor-associated factor 6,TRAF6 ELISA kit

The following TRAF6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TRAF6 Antibodies

TRAF6 Proteins

TRAF6 ELISA Kits

TRAF6 Antibodies

TRAF6 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA024154XA01DIL	traf6 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

TRAF6 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA024154GA01HU	TRAF6 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA004325	TRAF6 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA097438	TRAF6 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA954966	TRAF6 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA024154LA01HU	TRAF6 Antibody	Human	ELISA, IHC, IF
CSB-PA024154LB01HU	TRAF6 Antibody, HRP conjugated	Human	ELISA
CSB-PA024154LC01HU	TRAF6 Antibody, FITC conjugated	Human
CSB-RA037392A0HU	TRAF6 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF, FC

TRAF6 Proteins

TRAF6 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP024154DIL CSB-EP024154DIL CSB-BP024154DIL CSB-MP024154DIL CSB-EP024154DIL-B	Recombinant Danio rerio TNF receptor-associated factor 6 (traf6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP024154HU CSB-EP024154HU CSB-BP024154HU CSB-MP024154HU CSB-EP024154HU-B	Recombinant Human TNF receptor-associated factor 6 (TRAF6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP024154HU	Recombinant Human TNF receptor-associated factor 6 (TRAF6)	E.coli
CSB-EP024154HUe1	Recombinant Human TNF receptor-associated factor 6 (TRAF6)	E.coli

TRAF6 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP024154RA CSB-EP024154RA CSB-BP024154RA CSB-MP024154RA CSB-EP024154RA-B	Recombinant Rat TNF receptor-associated factor 6 (Traf6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP024154PI CSB-EP024154PI CSB-BP024154PI CSB-MP024154PI CSB-EP024154PI-B	Recombinant Pig TNF receptor-associated factor 6 (TRAF6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP024154MOW CSB-EP024154MOW CSB-BP024154MOW CSB-MP024154MOW CSB-EP024154MOW-B	Recombinant Macaca mulatta (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP024154BO CSB-EP024154BO CSB-BP024154BO CSB-MP024154BO CSB-EP024154BO-B	Recombinant Bovine TNF receptor-associated factor 6 (TRAF6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP024154XBF CSB-EP024154XBF CSB-BP024154XBF CSB-MP024154XBF CSB-EP024154XBF-B	Recombinant Xenopus tropicalis TNF receptor-associated factor 6 (traf6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP024154MO CSB-EP024154MO CSB-BP024154MO CSB-MP024154MO CSB-EP024154MO-B	Recombinant Mouse TNF receptor-associated factor 6 (Traf6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

Code	Product Name	Source
CSB-YP024154DRI CSB-EP024154DRI CSB-BP024154DRI CSB-MP024154DRI CSB-EP024154DRI-B	Recombinant Cercocebus atys TNF receptor-associated factor 6 (TRAF6), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF6 ELISA Kit

TRAF6 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E14078h	Human tumor necrosis factor receptor-associated factor 6,TRAF6 ELISA kit	serum, plasma, tissue homogenates, cell lysates	9.8 pg/mL

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TRAF6

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