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Recombinant Rat TNF receptor-associated factor 6 (Traf6)

Recombinant Rat TNF receptor-associated factor 6 (Traf6)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Traf6

Uniprot NO.

B5DF45

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-530

Target Protein Sequence

MSLLNCENSC ASSQSSSDCC AAMANSCSAA MKDDSVSGCV STGNLSSSFM EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL TVKCPNKGCV QKMELRHLED HQVHCEFALV ICPQCQRFFQ KCQINKHIIE DCPRRQVSCV NCAVPMPYEE KEIHDQSCPL ANIICEYCGT ILIREQMPNH YDLDCPTAPV PCTFSVFGCH EKMQRNHLAR HLQENTQLHM RLLAQAVHNV NLSLRPCDAS SPSRGCRPED PNYEETVKQL EGRLVRQDHQ IRELTAKMET QSMHVSELKR TIRSLEDKVA EMEAQQCNGI YIWKIGNFGM HLKSQEEERP VVIHSPGFYT GRPGYKLCMR LHLQLPTAQR CANYISLFVH TMQGEYDSHL PWPFQGTIRL TILDQSEAVI RQNHEEVMDA KPELLAFQRP TIPRNPKGFG YVTFMHLEAL RQGTFIKDDT LLVRCEVSTR FDMGGLRKEG FQPRSTDAGV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Gene References into Functions

miR-194 can inhibit lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc (IVD) by targeting TRAF6. PMID:29745371
showed that application of TRAF6 over-expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI after SAH, including neuronal death, brain edema, and blood-brain barrier injury PMID:28543180
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors PMID:27813153
As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions. PMID:27830143
increased in the heart of diabetic rats PMID:26925748
TRAF6 is involved in the pathophysiological process induced by cerebral ischemia-reperfusion and functions partially as a pro-inflammatory adaptor to mediate cell apoptosis. PMID:23001490
TRAF6 might play important roles in central nervous system pathophysiology after traumatic brain injury. PMID:21072581
Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. PMID:20659889
TRAF6 knockdown may inhibit inflammatory response and promote cell survival upon lipopolysaccharides in challenge in primary rat proximal renal tubular cells PMID:20136795
findings showed that TRAF6 might be associated with osteoclast differentiation in periapical lesions PMID:19482181