SERPINE1

SERPINE1, serine protease inhibitor family E member 1, alias PAI-1, PLANH1. It is a secreted glycoprotein encoded by the human gene SERPINE1, a member of the serine protease inhibitor superfamily, which is mainly produced in vascular endothelial cells but can also be secreted in other tissues such as adipose tissue.
The main mechanism of action of SERPINE1 is to regulate the coagulation and fibrinolytic system by inhibiting the activities of urokinase and tissue-type plasminogen activator (uPA and tPA).
SERPINE1 is involved in a variety of physiological and pathological processes, including fibrinolysis, fibrosis, angiogenesis, wound healing, and tumor cell invasion and metastasis. Aberrant SERPINE1 expression has been associated with a variety of diseases, such as metabolic syndrome, asthma, major depressive disorder, and aging-related disorders, and has been linked to a propensity for thrombosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SERPINE1 Recombinant Monoclonal Antibody(CSB-RA156066A0HU)

Validated Data

Western Blot
Positive WB detected in: U-251 whole cell lysate, U-87 whole cell lysate
All lanes: PAI1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46, 44 kDa
Observed band size: 45 kDa

IHC image of CSB-RA156066A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following SERPINE1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SERPINE1 Antibodies

SERPINE1 Proteins

SERPINE1 ELISA Kits

SERPINE1 Antibodies

SERPINE1 Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA021081ZA01RA	Serpine1 Antibody	Rattus norvegicus	ELISA, WB (ensure identification of antigen)

SERPINE1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA11239A0Rb	SERPINE1 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA021081GA01HU	SERPINE1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA11239B0Rb	SERPINE1 Antibody, HRP conjugated	Human	ELISA
CSB-PA003699	SERPINE1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA122189	SERPINE1 Antibody	Human,Rat	ELISA,IHC
CSB-EAP11239	SERPINE1 Antibody Pair	Human,Guinea pig,Bovine,Pig,Dog,Chicken,Goat	S-ELISA
CSB-RA156066A0HU	SERPINE1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA021081MA1HU	SERPINE1 Recombinant Monoclonal Antibody	Human	ELISA, WB, FC

SERPINE1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA021081ZA01MO	Serpine1 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

SERPINE1 Proteins

SERPINE1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-EP021081RA	Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1)	E.coli
CSB-YP021081RA CSB-EP021081RA CSB-BP021081RA CSB-MP021081RA CSB-EP021081RA-B	Recombinant Rat Plasminogen activator inhibitor 1 (Serpine1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SERPINE1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP021081HU CSB-EP021081HU CSB-BP021081HU CSB-MP021081HU CSB-EP021081HU-B	Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP021081HU1	Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1), partial	E.coli
CSB-EP021081HU1e0	Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1), partial	E.coli
CSB-MP021081HU	Recombinant Human Plasminogen activator inhibitor 1 (SERPINE1)	Mammalian cell

SERPINE1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP021081PI CSB-EP021081PI CSB-BP021081PI CSB-MP021081PI CSB-EP021081PI-B	Recombinant Pig Plasminogen activator inhibitor 1 (SERPINE1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SERPINE1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP021081BO CSB-EP021081BO CSB-BP021081BO CSB-MP021081BO CSB-EP021081BO-B	Recombinant Bovine Plasminogen activator inhibitor 1 (SERPINE1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SERPINE1 Proteins for Neovison vison (American mink) (Mustela vison)

Code	Product Name	Source
CSB-YP021081MVE CSB-EP021081MVE CSB-BP021081MVE CSB-MP021081MVE CSB-EP021081MVE-B	Recombinant Mustela vison Plasminogen activator inhibitor 1 (SERPINE1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SERPINE1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP021081MO	Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)	Yeast
CSB-EP021081MO	Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)	E.coli
CSB-YP021081MO CSB-EP021081MO CSB-BP021081MO CSB-MP021081MO CSB-EP021081MO-B	Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SERPINE1 ELISA Kit

SERPINE1 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E07948r	Rat plasminogen activator inhibitor 1,PAI1 ELISA Kit	serum, plasma, tissue homogenates	19.5 pg/ml

SERPINE1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E07946h	Human plasminogen activator inhibitor 1,PAI-1 ELISA Kit	serum, plasma, tissue homogenates	2.201 ng/mL

SERPINE1 ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E06534p	Pig plasminogen activator inhibitor 1,PAI-1 ELISA Kit	serum, plasma, tissue homogenates	0.078 ng/mL

SERPINE1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E07947m	Mouse plasminogen activator inhibitor 1,PAI-1 ELISA Kit	serum, plasma, tissue homogenates	0.22 ng/mL

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