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Recombinant Bovine Plasminogen activator inhibitor 1 (SERPINE1)

Recombinant Bovine Plasminogen activator inhibitor 1 (SERPINE1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

SERPINE1

Uniprot NO.

P13909

Alternative Names

SERPINE1; PAI1; Plasminogen activator inhibitor 1; PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

24-402

Target Protein Sequence

SYQPQSA AASLATDFGV KVFQQVVRAS KDRNVVFSPY GVASVLAMLQ LTTGGETRQQ IQEAMQFKIE EKGMAPAFHR LYKELMGPWN KDEISTADAI FVQRDLELVH GFMPNFFRLF RTTVKQVDFS EVERARFIVN DWVKRHTKGM ISDLLGEGAV DQLTRLVLVN ALYFNGQWKM PFPESNTHHR LFHKSDGSTI SVPMMAQTNK FNYTEFTTPD GRYYDILELP YHGNTLSMLI AAPYEKEVPL SALTSILDAE LISQWKGNMT RLTRLLVLPK FSLETEIDLR RPLENLGMTD MFRPSQADFS SFSDQEFLYV SQALQKVKIE VNESGTLASS STALVVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.

Gene References into Functions

Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes. PMID:25939353
Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue/stress stimulation. PMID:21596853
the PI3K/Akt pathway acts as a negative regulator of PAI-1 expression in vascular endothelial cells, in part, through the downregulation of MAPK pathways PMID:17172275
high glucose-induced plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells is mediated by NF-kappaB activation through the Rho/Rho-kinase pathway PMID:17275007
FoxO1 inhibits PAI-1 expression through the inhibition of TGF-beta/Smad-mediated signaling pathways. PMID:19563779