HAVCR1

HAVCR1, also known as Hepatitis A virus cellular receptor 1, is commonly referred to as TIM - 1 (T - cell immunoglobulin and mucin domain - containing protein 1). It plays a pivotal role in the immune response. HAVCR1 can bind to phosphatidylserine on the surface of apoptotic cells, facilitating their clearance. It is involved in the T - cell activation and differentiation pathways.
Dysregulation of HAVCR1 has been associated with various diseases, such as autoimmune disorders and certain cancers. In the field of drug development, there is growing interest in targeting HAVCR1. Some monoclonal antibodies are under research to modulate its function, aiming to improve the treatment of related diseases.