Recombinant Rat Hepatitis A virus cellular receptor 1 homolog (Havcr1)

1. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID:29045706
2. urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID:28075469
3. Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID:27231899
4. blood biomarker that specifically reflects acute and chronic kidney injury PMID:24904085
5. Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID:22898836
6. These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID:22984472
7. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID:21905055
8. The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID:20660082
9. Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID:20458318
10. KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID:20305092
11. Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID:16174863
12. These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID:16467126
13. Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID:16896183
14. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID:17934191
15. Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID:18414680
16. on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID:19225054
17. Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID:19371613
18. Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID:19371616
19. Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID:19387469
20. Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID:19522876

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UNIGENE: Rn.11154

KEGG: rno:286934

STRING: 10116.ENSRNOP00000009573