CPT1A

CPT1A, also known as carnitine palmitoyltransferase 1A, is a mitochondrial enzyme responsible for the formation of acyl carnitines. It catalyzes the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine, facilitating fatty acid beta-oxidation. CPT1A is associated with the outer mitochondrial membrane and is regulated by malonyl-CoA. It is involved in fatty acid metabolism and is linked to metabolic disorders such as diabetes and obesity.
CPT1A functions as a key enzyme in fatty acid transport and metabolism, playing a crucial role in the regulation of cellular energy homeostasis. Its dysregulation is associated with various diseases, including Carnitine Palmitoyltransferase I Deficiency and type 2 diabetes. Research on CPT1A has led to potential therapeutic targets for metabolic disorders, with ongoing drug development focusing on modulating its activity.