CD14

CD14, also known as Cluster of Differentiation 14, is a glycosylphosphatidylinositol (GPI)-anchored protein. Common aliases include LPS receptor. Its main mechanism is to bind lipopolysaccharide (LPS) in complex with LPS-binding protein (LBP), initiating an immune response. It participates in the Toll-like receptor 4 (TLR4) signaling pathway.
CD14 has been associated with various diseases such as sepsis and inflammatory bowel disease. In drug development, targeting CD14 is being explored as a strategy to modulate the over - activated immune response. Some small - molecule inhibitors are in pre - clinical studies, aiming to control the excessive inflammation mediated by CD14.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD14 at 2 μg/ml on an Nickel Coated plate can bind Anti-CD14 recombinant antibody (CSB-RA004879MA1HU). The EC₅₀ is 2.148-2.447 ng/mL.

Recombinant Human Monocyte differentiation antigen CD14 (CD14)(CSB-EP004879HU)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD14 Recombinant Monoclonal Antibody(CSB-RA004879MA1HU)

Validated Data

CD14 Recombinant Monoclonal Antibody

Human soluble cluster of differentiation 14,sCD14 ELISA Kit(CSB-E13199h)

Validated Data

Human soluble cluster of differentiation 14,sCD14 ELISA Kit

The following CD14 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CD14 Antibodies

CD14 Proteins

CD14 ELISA Kits

CD14 Antibodies

CD14 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA004879GA01HU	CD14 Antibody	Human	ELISA,WB,IHC
CSB-PA07085A0Rb	CD14 Antibody	Human	ELISA, IHC, IF
CSB-PA07085B0Rb	CD14 Antibody, HRP conjugated	Human	ELISA
CSB-PA07085C0Rb	CD14 Antibody, FITC conjugated	Human
CSB-PA07085D0Rb	CD14 Antibody, Biotin conjugated	Human	ELISA
CSB-MA004879A0m	CD14 Monoclonal Antibody	Human, Mouse, Rabbit	ELISA, WB, IF, FC
CSB-MA004879A1m	CD14 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF
CSB-MA792948	CD14 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA004879MA1HU	CD14 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA004879MB1HU	CD14 (atibuclimab Biosimilar) Recombinant Monoclonal Antibody	Human

CD14 Proteins

CD14 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP737216RA CSB-EP737216RA CSB-BP737216RA CSB-MP737216RA CSB-EP737216RA-B	Recombinant Rat Monocyte differentiation antigen CD14 (Cd14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP638942RB CSB-EP638942RB CSB-BP638942RB CSB-MP638942RB CSB-EP638942RB-B	Recombinant Rabbit Monocyte differentiation antigen CD14 (CD14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP004879HU CSB-EP004879HU CSB-BP004879HU CSB-MP004879HU CSB-EP004879HU-B	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004879HU	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	E.coli
CSB-MP004879HU	Recombinant Human Monocyte differentiation antigen CD14 (CD14)	Mammalian cell
CSB-MP004879HU1	Recombinant Human Monocyte differentiation antigen CD14 (CD14), partial (Active)	Mammalian cell

CD14 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP839154BO CSB-EP839154BO CSB-BP839154BO CSB-MP839154BO CSB-EP839154BO-B	Recombinant Bovine Monocyte differentiation antigen CD14 (CD14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP004879MO CSB-EP004879MO CSB-BP004879MO CSB-MP004879MO CSB-EP004879MO-B	Recombinant Mouse Monocyte differentiation antigen CD14 (Cd14)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD14 ELISA Kit

CD14 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E11178r	Rat soluble cluster of differentiation 14,sCD14 ELISA Kit	serum, plasma, tissue homogenates	7 ng/mL

CD14 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E13199h	Human soluble cluster of differentiation 14,sCD14 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, urine	0.229 ng/mL

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CD14

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