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Recombinant Bovine Monocyte differentiation antigen CD14 (CD14)

Recombinant Bovine Monocyte differentiation antigen CD14 (CD14)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CD14

Purity

>85% (SDS-PAGE)

Target Names

CD14

Uniprot NO.

Q95122

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

21-373

Target Protein Sequence

DTTEPCELDD DDFRCVCNFT DPKPDWSSAV QCMVAVEVEI SAGGRSLEQF LKGADTNPKQ YADTIKALRV RRLKLGAAQV PAQLLVAVLR ALGYSRLKEL TLEDLEVTGP TPPTPLEAAG PALTTLSLRN VSWTTGGAWL GELQQWLKPG LRVLNIAQAH SLAFPCAGLS TFEALTTLDL SDNPSLGDSG LMAALCPNKF PALQYLALRN AGMETPSGVC AALAAARVQP QSLDLSHNSL RVTAPGATRC VWPSALRSLN LSFAGLEQVP KGLPPKLSVL DLSCNKLSRE PRRDELPEVN DLTLDGNPFL DPGALQHQND PMISGVVPAC ARSALTMGVS GALALLQGAR GFA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).

Gene References into Functions

the CD14 single nucleotide polymorphisms identified in the present study, may be closely associated with the morbidity of mastitis. PMID:28990093
results suggest that -5C/T and 613G/A single-nucleotide polymorphisms are risk factors for bovine tuberculosis in Chinese Holstein cattle PMID:29428082
Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. PMID:26777563
Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of CD14 and TLR4 (toll-like receptor 4). PMID:23077171
This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN), resident PMN and inflammatory PMN from heifer mammary glands was accompanied by apoptosis and necrosis. PMID:20599238
data are consistent with a role for lipopolysaccharide binding protein and soluble CD14 antigen molecules in mediating mammary gland responses to lipopolysaccharide(lipopolysaccharide binding protein- LBP) PMID:14594231
Toll-like receptor 4 mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry. PMID:16223858
First report of a functionally active animal receptor protein made in plants and the prophylactic use of a plant-derived protein to reduce the severity of bacterial infections in animals. PMID:16816109
SNP and association analyses have provided baseline information that may be used at defining the role of CD14 in mediating bacterial infections PMID:18691417